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Literature summary extracted from

  • Veeravalli, S.; Phillips, I.R.; Freire, R.T.; Varshavi, D.; Everett, J.R.; Shephard, E.A.
    Flavin-containing monooxygenase 1 catalyzes the production of taurine from hypotaurine (2020), Drug Metab. Dispos., 48, 378-385 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.13.8 additional information construction of Fmo1-/-, 2-/-, and 4-/- knockout mutants, 1D 1H NMR spectroscopy to compare the urinary metabolite profiles of the knockout-mouse line and wild-type animals, metabolic profiles of hypotaurine and taurine in wild-type and mutant mice' urine samples, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.8 membrane
-
 Homo sapiens 16020
-
1.14.13.8 membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.8 hypotaurine + NADH + H+ + O2 Homo sapiens S-oxygenation taurine + NAD+ + H2O
-
 ?
1.14.13.8 hypotaurine + NADH + H+ + O2 Mus musculus S-oxygenation taurine + NAD+ + H2O
-
 ?
1.14.13.8 hypotaurine + NADPH + H+ + O2 Homo sapiens S-oxygenation taurine + NADP+ + H2O
-
 ?
1.14.13.8 hypotaurine + NADPH + H+ + O2 Mus musculus S-oxygenation taurine + NADP+ + H2O
-
 ?
1.14.13.8 N,N-dimethylaniline + NADPH + H+ + O2 Homo sapiens
-
 N,N-dimethylaniline N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 N,N-dimethylaniline + NADPH + H+ + O2 Mus musculus
-
 N,N-dimethylaniline N-oxide + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Homo sapiens
-
-
-
1.14.13.8 Homo sapiens Q01740
-
-
1.14.13.8 Mus musculus P50285
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.8 brain
-
 Homo sapiens
-
1.14.13.8 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 hypotaurine + NADH + H+ + O2 S-oxygenation Homo sapiens taurine + NAD+ + H2O
-
 ?
1.14.13.8 hypotaurine + NADH + H+ + O2 S-oxygenation Mus musculus taurine + NAD+ + H2O
-
 ?
1.14.13.8 hypotaurine + NADPH + H+ + O2 S-oxygenation Homo sapiens taurine + NADP+ + H2O
-
 ?
1.14.13.8 hypotaurine + NADPH + H+ + O2 S-oxygenation Mus musculus taurine + NADP+ + H2O
-
 ?
1.14.13.8 hypotaurine + O2 + NADH + H+
-
 Homo sapiens taurine + NAD+ + H2O
-
 ?
1.14.13.8 hypotaurine + O2 + NADPH + H+
-
 Homo sapiens taurine + NADP+ + H2O
-
 ?
1.14.13.8 methimazole + NADH + H+
-
 Homo sapiens ?
-
 ?
1.14.13.8 methimazole + NADPH + H+
-
 Homo sapiens ?
-
 ?
1.14.13.8 methimazole + NADPH + H+ + O2 S-oxygenation Homo sapiens methimazole S-oxide + NADP+ + H2O
-
 ?
1.14.13.8 methimazole + NADPH + H+ + O2 S-oxygenation Mus musculus methimazole S-oxide + NADP+ + H2O
-
 ?
1.14.13.8 additional information human FMO1 catalyzes the oxygenation of hypotaurine in vitro. Ability of hypotaurine to act as a competitor substrate of FMO1 is assessed by measuring the effect of various concentrations of hypotaurine on FMO1-catalyzed S-oxygenation of methimazole Homo sapiens ?
-
-
1.14.13.8 N,N-dimethylaniline + NADPH + H+ + O2
-
 Homo sapiens N,N-dimethylaniline N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 N,N-dimethylaniline + NADPH + H+ + O2
-
 Mus musculus N,N-dimethylaniline N-oxide + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.8 flavin-containing monooxygenase 1
-
 Homo sapiens
1.14.13.8 flavin-containing monooxygenase 1
-
 Mus musculus
1.14.13.8 FMO1
-
 Homo sapiens
1.14.13.8 FMO1
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.8 37
-
 assay at Homo sapiens
1.14.13.8 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.8 8.5
-
 assay at Homo sapiens
1.14.13.8 8.5
-
 assay at Mus musculus
1.14.13.8 8.5
-
 most active at pH 8.5 with NADPH as cofactor Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 FAD
-
 Homo sapiens
1.14.13.8 FAD
-
 Mus musculus
1.14.13.8 additional information enzyme FMO1 can use either NADPH or NADH as cofactor Homo sapiens
1.14.13.8 additional information enzyme FMO1 can use either NADPH or NADH as cofactor Mus musculus
1.14.13.8 NADH
-
 Homo sapiens
1.14.13.8 NADH
-
 Mus musculus
1.14.13.8 NADH whereas NADPH is the more effective cofactor at pH 8.5, the cofactors are equally effective at pH 7.4 Homo sapiens
1.14.13.8 NADPH
-
 Homo sapiens
1.14.13.8 NADPH
-
 Mus musculus
1.14.13.8 NADPH whereas NADPH is the more effective cofactor at pH 8.5, the cofactors are equally effective at pH 7.4 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.13.8 malfunction FMO1 malfunction causes taurine deficiency, which is implicated in a number of pathologic conditions, including cardiomyopathy, muscular abnormalities, and renal dysfunction Homo sapiens
1.14.13.8 malfunction FMO1 malfunction causes taurine deficiency, which is implicated in a number of pathologic conditions, including cardiomyopathy, muscular abnormalities, and renal dysfunction Mus musculus
1.14.13.8 physiological function the formation of taurine from hypotaurine is catalyzed by an FMO in vivo, it is the terminal step of the biosynthetic pathway of taurine production from cysteine Homo sapiens
1.14.13.8 physiological function the formation of taurine from hypotaurine is catalyzed by an FMO in vivo, it is the terminal step of the biosynthetic pathway of taurine production from cysteine Mus musculus