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Literature summary extracted from

  • Barsottini, M.; Copsey, A.; Young, L.; Baroni, R.; Cordeiro, A.; Pereira, G.; Moore, A.
    Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa (2020), Commun. Biol., 3, 263 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.10.3.11 expression in Escherichia coli Moniliophthora perniciosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.3.11 colletochlorin B mixed-type inhibitor Moniliophthora perniciosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.10.3.11 0.0685
-
ubiquinol-1 pH 7.4, temperature not specified in the publication Moniliophthora perniciosa
1.10.3.11 0.96
-
ubiquinol-10 pH 7.4, temperature not specified in the publication Moniliophthora perniciosa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.10.3.11 membrane membrane-bound enzyme Moniliophthora perniciosa 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.3.11 2 ubiquinol + O2 Moniliophthora perniciosa
-
2 ubiquinone + 2 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.11 Moniliophthora perniciosa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.3.11
-
Moniliophthora perniciosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.11 2 ubiquinol + O2
-
Moniliophthora perniciosa 2 ubiquinone + 2 H2O
-
?
1.10.3.11 2 ubiquinol-1 + O2
-
Moniliophthora perniciosa 2 ubiquinone-1 + 2 H2O
-
?
1.10.3.11 2 ubiquinol-10 + O2
-
Moniliophthora perniciosa 2 ubiquinone-10 + 2 H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.10.3.11 alternative oxidase
-
Moniliophthora perniciosa
1.10.3.11 MpAOX
-
Moniliophthora perniciosa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.10.3.11 0.0000593
-
pH 7.4, temperature not specified in the publication Moniliophthora perniciosa colletochlorin B

General Information

EC Number General Information Comment Organism
1.10.3.11 drug target the development of AOX-targeting antifungal agents against Moniliophthora perniciosa is an important outcome for the chocolate industry Moniliophthora perniciosa
1.10.3.11 physiological function the enzyme (MpAOX) is crucial for survival the fungal pathogen Moniliophthora perniciosa (causal agent of the witches' broom disease of cocoa) Moniliophthora perniciosa