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Literature summary extracted from

  • Coutant, E.P.; Gagnot, G.; Hervin, V.; Baatallah, R.; Goyard, S.; Jacob, Y.; Rose, T.; Janin, Y.L.
    Bioluminescence profiling of nanoKAZ/nanoLuc luciferase using a chemical library of coelenterazine analogues (2020), Chemistry, 26, 948-958 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.12.13 2,8-dibenzyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 2-[(5-ethylfuran-2-yl)methyl]-8-[(2-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 2-[(5-ethylfuran-2-yl)methyl]-8-[(3-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 2-[(5-methylfuran-2-yl)methyl]-8-[(3-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 6-(2-fluorophenyl)-8-[(4-fluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-benzyl-2-[(2-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-benzyl-2-[(3-methylphenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-benzyl-2-[(furan-2-yl)methyl]-6-(3-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-benzyl-2-[(furan-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-benzyl-2-[[3-(furan-2-yl)phenyl]methyl]-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-benzyl-6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-benzyl-6-(4-hydroxyphenyl)-2-[(5-methylfuran-2-yl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-[(2,3-difluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-[(2-fluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-[(3,5-difluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 8-[(3,5-difluorophenyl)methyl]-2-[(furan-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
-
 Oplophorus gracilirostris
1.13.12.13 coelenterazine
-
 Oplophorus gracilirostris
1.13.12.13 h-coelenterazine
-
 Oplophorus gracilirostris

Organism

EC Number Organism UniProt Comment Textmining
1.13.12.13 Oplophorus gracilirostris Q9GV45 AND Q9GV46 Q9GV45: catalytic subunit, Q9GV46: non-catalytic subunit
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.12.13 0.022
-
 coelenterazine pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.035
-
 8-benzyl-6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.04
-
 2-[(5-methylfuran-2-yl)methyl]-8-[(3-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.058
-
 8-benzyl-2-[(2-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.06
-
 2-[(5-ethylfuran-2-yl)methyl]-8-[(3-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.06
-
 8-[(2-fluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.063
-
 6-(2-fluorophenyl)-8-[(4-fluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.064
-
 8-[(3,5-difluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.08
-
 8-[(2,3-difluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.084
-
 8-benzyl-2-[(furan-2-yl)methyl]-6-(3-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.095
-
 2-[(5-ethylfuran-2-yl)methyl]-8-[(2-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.101
-
 h-coelenterazine pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.101
-
 8-benzyl-2-[[3-(furan-2-yl)phenyl]methyl]-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.109
-
 8-benzyl-2-[(furan-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.115
-
 2,8-dibenzyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.121
-
 8-benzyl-6-(4-hydroxyphenyl)-2-[(5-methylfuran-2-yl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.14
-
 8-[(3,5-difluorophenyl)methyl]-2-[(furan-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris
1.13.12.13 0.167
-
 8-benzyl-2-[(3-methylphenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one pH and temperature not specified in the publication Oplophorus gracilirostris