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Literature summary extracted from

  • Jin, Z.; Zhou, L.; Tian, R.; Lu, N.
    Myeloperoxidase targets apolipoprotein A-I for site-specific tyrosine chlorination in atherosclerotic lesions and generates dysfunctional high-density lipoprotein (2021), Chem. Res. Toxicol., 34, 1672-1680 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.2.2 Cl- + H2O2 + H+ Homo sapiens
-
HClO + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.11.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.2.2 blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.2.2 apolipoprotein A-I + H2O2 + H+
-
Homo sapiens ?
-
?
1.11.2.2 Cl- + H2O2 + H+
-
Homo sapiens HClO + H2O
-
?
1.11.2.2 additional information compared with native apolipoprotein A-I, apolipoprotein A-I containing a Y192F mutation is moderately resistant to oxidative inactivation by the enzyme Homo sapiens ?
-
-

Synonyms

EC Number Synonyms Comment Organism
1.11.2.2 MPO
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.2.2 heme
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.11.2.2 metabolism enzyme-mediated damage of lipid-free apolipoprotein A-I impairs its ability to promote cellular cholesterol efflux by the ABCA1 pathway, whereas oxidation to lipid-associated apolipoprotein A-I inhibits lecithin:cholesterol acyltransferase activation, two key steps in reverse cholesterol transport Homo sapiens