Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Korwar, S.; Morris, B.; Parikh, H.; Coover, R.; Doughty, T.; Love, I.; Hilbert, B.; Royer, W.J.; Kellogg, G.; Grossman, S.; Ellis, K.
    Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal binding protein (CtBP) (2016), Bioorg. Med. Chem., 24, 2707-2715 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.428 (2Z)-2-(hydroxyimino)-3-phenylpropanoic acid potent inhibitor Homo sapiens
1.1.1.428 (2Z)-2-hydrazinylidene-3-phenylpropanoic acid
-
 Homo sapiens
1.1.1.428 1-phenylpropan-2-one
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-(2-methoxyphenyl)propanoic acid
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-(3-hydroxyphenyl)propanoic acid
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-(3-methoxyphenyl)propanoic acid
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-(4-hydroxyphenyl)propanoic acid
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-(4-methoxyphenyl)propanoic acid
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-m-tolylpropanoic acid
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-o-tolylpropanoic acid
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-p-tolylpropanoic acid
-
 Homo sapiens
1.1.1.428 2-(hydroxyimino)-3-phenylpropanoic acid potent inhibitor Homo sapiens
1.1.1.428 2-benzylprop-2-enoic acid
-
 Homo sapiens
1.1.1.428 2-hydrazono-3-phenylpropanoic acid
-
 Homo sapiens
1.1.1.428 2-Oxopropanoic acid
-
 Homo sapiens
1.1.1.428 3-(2-chlorophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
1.1.1.428 3-(3-chlorophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
1.1.1.428 3-(4-chlorophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
1.1.1.428 3-(4-cyanophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
1.1.1.428 3-(4-fluorophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
1.1.1.428 3-phenyl-2-thioxopropanoic acid
-
 Homo sapiens
1.1.1.428 3-Phenylpropanoic acid
-
 Homo sapiens
1.1.1.428 4-(methylsulfanyl)-2-oxobutanoate substrate inhibition Homo sapiens
1.1.1.428 benzylpropanedioic acid
-
 Homo sapiens
1.1.1.428 oxo(phenyl)acetic acid
-
 Homo sapiens
1.1.1.428 oxo(phenylamino)acetic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.428 4-(methylsulfanyl)-2-oxobutanoate + NADH + H+ Homo sapiens
-
 (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.428 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.428 colorectal cancer cell
-
 Homo sapiens
-
1.1.1.428 HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.428 4-(methylsulfanyl)-2-oxobutanoate + NADH + H+
-
 Homo sapiens (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.428 C-terminal-binding protein 1
-
 Homo sapiens
1.1.1.428 CtBP
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.428 NADH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.428 0.00017
-
 at pH 7.1 and 25°C Homo sapiens 3-(3-chlorophenyl)-2-(hydroxyimino)propanoic acid
1.1.1.428 0.00018
-
 at pH 7.1 and 25°C Homo sapiens 3-(4-chlorophenyl)-2-(hydroxyimino)propanoic acid
1.1.1.428 0.00024
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-phenylpropanoic acid
1.1.1.428 0.0003
-
 at pH 7.1 and 25°C Homo sapiens 3-(4-fluorophenyl)-2-(hydroxyimino)propanoic acid
1.1.1.428 0.00032
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-p-tolylpropanoic acid
1.1.1.428 0.00048
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-m-tolylpropanoic acid
1.1.1.428 0.00072
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(3-hydroxyphenyl)propanoic acid
1.1.1.428 0.00088
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(3-methoxyphenyl)propanoic acid
1.1.1.428 0.0009
-
 at pH 7.1 and 25°C Homo sapiens 3-(4-cyanophenyl)-2-(hydroxyimino)propanoic acid
1.1.1.428 0.00216
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(4-methoxyphenyl)propanoic acid
1.1.1.428 0.0024
-
 at pH 7.1 and 25°C Homo sapiens (2Z)-2-(hydroxyimino)-3-phenylpropanoic acid
1.1.1.428 0.00734
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(4-hydroxyphenyl)propanoic acid
1.1.1.428 0.00765
-
 at pH 7.1 and 25°C Homo sapiens 3-(2-chlorophenyl)-2-(hydroxyimino)propanoic acid
1.1.1.428 0.00873
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-o-tolylpropanoic acid
1.1.1.428 0.1
-
 IC50 above 0.1 mM, at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(2-methoxyphenyl)propanoic acid
1.1.1.428 300
-
 at pH 7.1 and 25°C Homo sapiens 4-(methylsulfanyl)-2-oxobutanoate