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Literature summary extracted from

  • Boschanski, M.; Krueger, T.; Karsten, L.; Falck, G.; Alam, S.; Gerlach, M.; Mueller, B.; Mueller, K.M.; Sewald, N.; Dierks, T.
    Site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes (2021), Bioconjug. Chem., 32, 1167-1174 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.8.3.7 biotechnology site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes Mycobacterium tuberculosis
1.8.3.7 biotechnology site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes Streptomyces coelicolor
1.8.3.7 biotechnology site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.3.7 Cu2+ the substrate specificity for the cysteine motifs CTPS is not changed upon addition of the cofactor copper Homo sapiens
1.8.3.7 Cu2+ Cu2+-treated enzyme converts both cysteine motifs (CTPSR and CTAGR) Mycobacterium tuberculosis
1.8.3.7 Cu2+ Cu2+-treated enzyme converts both cysteine motifs (CTPSR and CTAGR) Streptomyces coelicolor

Organism

EC Number Organism UniProt Comment Textmining
1.8.3.7 Homo sapiens Q8NBK3
-
-
1.8.3.7 Mycobacterium tuberculosis
-
-
-
1.8.3.7 Streptomyces coelicolor
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.3.7 Ac-EQSCTAGRAAFITGQGLCTPSRAG-NH2 + O2 + a thiol accepts the sequence CTPSR. The human enzyme strictly convertes proline-containing aldehyde tags, either in vivo or in vitro, whereas in the presence of copper, the enzyme fom Streptomyces coelicolor and Mycobacterium tuberculosis tolerate proline-to-alanine substitutions in the core motif Mycobacterium tuberculosis ?
-
 ?
1.8.3.7 Ac-EQSCTAGRAAFITGQGLCTPSRAG-NH2 + O2 + a thiol accepts the sequence CTPSR. The human enzyme strictly convertes proline-containing aldehyde tags, either in vivo or in vitro, whereas in the presence of copper, the enzyme fom Streptomyces coelicolor and Mycobacterium tuberculosis tolerate proline-to-alanine substitutions in the core motif Streptomyces coelicolor ?
-
 ?
1.8.3.7 Ac-EQSCTAGRAAFITGQGLCTPSRAG-NH2 + O2 + reduced dithiothreitol accepts the sequence CTPSR. The human enzyme strictly converts proline-containing aldehyde tags, either in vivo or in vitro, whereas in the presence of copper, the enzyme fom Streptomyces coelicolor and Mycobacterium tuberculosis tolerate proline-to-alanine substitutions in the core motif Homo sapiens ? + hydrogen sulfide + oxidized dithiothreitol + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.3.7 FGE
-
 Mycobacterium tuberculosis
1.8.3.7 FGE
-
 Streptomyces coelicolor
1.8.3.7 FGE
-
 Homo sapiens