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Literature summary extracted from

  • Shiba, T.; Inaoka, D.; Takahashi, G.; Tsuge, C.; Kido, Y.; Young, L.; Ueda, S.; Balogun, E.; Nara, T.; Honma, T.; Tanaka, A.; Inoue, M.; Saimoto, H.; Harada, S.; Moore, A.; Kita, K.
    Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase (2019), Biochim. Biophys. Acta Bioenerg., 1860, 375-382 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.3.11 ascofuranone quasi-irreversible inhibitor Trypanosoma brucei brucei
1.10.3.11 ferulenol competitive inhibitor, binding is completely reversible Trypanosoma brucei brucei

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.10.3.11 Iron diiron enzyme Trypanosoma brucei brucei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.3.11 2 ubiquinol + O2 Trypanosoma brucei brucei
-
 2 ubiquinone + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.11 Trypanosoma brucei brucei Q26710
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.11 2 ubiquinol + O2
-
 Trypanosoma brucei brucei 2 ubiquinone + 2 H2O
-
 ?
1.10.3.11 2 ubiquinol-1 + O2
-
 Trypanosoma brucei brucei 2 ubiquinone-1 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.10.3.11 alternative oxidase
-
 Trypanosoma brucei brucei
1.10.3.11 AOX
-
 Trypanosoma brucei brucei

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.10.3.11 0.00000133
-
 ferulenol pH 7.4, 25°C Trypanosoma brucei brucei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.10.3.11 0.000000288
-
 pH 7.4, 25°C Trypanosoma brucei brucei ascofuranone
1.10.3.11 0.00000142
-
 pH 7.4, 25°C Trypanosoma brucei brucei ferulenol