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Literature summary extracted from

  • Meco-Navas, A.; Ebiloma, G.; Martinguez, A.; Martinez-Benayas, I.; Cueto-Diaz, E.; Alhejely, A.; Balogun, E.; Saito, M.; Matsui, M.; Arai, N.; Shiba, T.; Harada, S.; De Koning, H.; Dardonville, C.
    SAR of 4-alkoxybenzoic acid inhibitors of the Trypanosome alternative oxidase (2018), ACS Med. Chem. Lett., 9, 923-928 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.3.11 2,6-dihydroxy-4-[[(2E,6E,10E)-12-hydroxy-2,6,10-trimethyldodeca-2,6,10-trien-1-yl]oxy]benzoic acid
-
 Trypanosoma brucei brucei
1.10.3.11 2-fluoro-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid
-
 Trypanosoma brucei brucei
1.10.3.11 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-6-methylbenzoic acid
-
 Trypanosoma brucei brucei
1.10.3.11 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid
-
 Trypanosoma brucei brucei
1.10.3.11 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzaldehyde
-
 Trypanosoma brucei brucei
1.10.3.11 4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-2-methylbenzoic acid
-
 Trypanosoma brucei brucei
1.10.3.11 ascofuranone
-
 Trypanosoma brucei brucei
1.10.3.11 methyl 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoate
-
 Trypanosoma brucei brucei
1.10.3.11 methyl 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzoate
-
 Trypanosoma brucei brucei
1.10.3.11 Salicylhydroxamic acid
-
 Trypanosoma brucei brucei
1.10.3.11 [14-(4-carboxy-3-hydroxy-5-methylphenoxy)tetradecyl](triphenyl)phosphanium
-
 Trypanosoma brucei brucei
1.10.3.11 [14-(4-formyl-3-hydroxyphenoxy)tetradecyl](triphenyl)phosphanium
-
 Trypanosoma brucei brucei
1.10.3.11 [14-[3-fluoro-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
-
 Trypanosoma brucei brucei
1.10.3.11 [14-[3-hydroxy-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
-
 Trypanosoma brucei brucei
1.10.3.11 [14-[4-(ethoxycarbonyl)-3-hydroxy-5-methylphenoxy]tetradecyl](triphenyl)phosphanium
-
 Trypanosoma brucei brucei
1.10.3.11 [14-[4-hydroxy-3-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
-
 Trypanosoma brucei brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.10.3.11 membrane bound to Trypanosoma brucei brucei 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.10.3.11 Iron diiron protein Trypanosoma brucei brucei

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.11 Trypanosoma brucei brucei Q26710
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.3.11
-
 Trypanosoma brucei brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.11 2 ubiquinol + O2
-
 Trypanosoma brucei brucei 2 ubiquinone + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.10.3.11 alternative oxidase
-
 Trypanosoma brucei brucei
1.10.3.11 TAO
-
 Trypanosoma brucei brucei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.10.3.11 0.000002
-
 pH and temperature not specified in the publication Trypanosoma brucei brucei ascofuranone
1.10.3.11 0.0000031
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei 2,6-dihydroxy-4-[[(2E,6E,10E)-12-hydroxy-2,6,10-trimethyldodeca-2,6,10-trien-1-yl]oxy]benzoic acid
1.10.3.11 0.0000042
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei [14-(4-carboxy-3-hydroxy-5-methylphenoxy)tetradecyl](triphenyl)phosphanium
1.10.3.11 0.000012
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei [14-[4-hydroxy-3-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
1.10.3.11 0.000015
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei [14-[3-hydroxy-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
1.10.3.11 0.0000176
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzaldehyde
1.10.3.11 0.00022
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei [14-(4-formyl-3-hydroxyphenoxy)tetradecyl](triphenyl)phosphanium
1.10.3.11 0.00025
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei [14-[4-(ethoxycarbonyl)-3-hydroxy-5-methylphenoxy]tetradecyl](triphenyl)phosphanium
1.10.3.11 0.00074
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei [14-[3-fluoro-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
1.10.3.11 0.00092
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei 4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-2-methylbenzoic acid
1.10.3.11 0.0011
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei 2-fluoro-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid
1.10.3.11 0.00169
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei methyl 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoate
1.10.3.11 0.0021
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid
1.10.3.11 0.0023
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei methyl 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzoate
1.10.3.11 0.0024
-
 37°C, pH not specified in the publication Trypanosoma brucei brucei 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-6-methylbenzoic acid
1.10.3.11 0.00593
-
 pH and temperature not specified in the publication Trypanosoma brucei brucei Salicylhydroxamic acid

General Information

EC Number General Information Comment Organism
1.10.3.11 drug target validated as a drug target against trypanosomes Trypanosoma brucei brucei
1.10.3.11 physiological function critical enzyme for the respiration of bloodstream forms of trypanosomes Trypanosoma brucei brucei