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Literature summary extracted from

  • Ahmad, I.; Pawara, R.; Surana, S.; Patel, H.
    The Repurposed ACE2 Inhibitors SARS-CoV-2 entry blockers of covid-19 (2021), Top. Curr. Chem., 379, 40 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 6-gingerol inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 amentoflvaone inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 andrographolide inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 apigenin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 arbidol inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 artemisnin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 asparoside C inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 AY-NH2 inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 Berberine inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 beta-sitosterol inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 bis-demethoxy curcumin inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 cepharanthine potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 chebulagic acid inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 crisimaritin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 cucurbitacin B inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 curcumin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 cynaropicrin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 darunavir inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 denopamine inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 dithymoquinone inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 ergoloid potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 eriodictyol potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 favipiravir potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 hesperidin inhibition of the ACE2 enzyme; inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 hispudulin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 hydroxychloroquine potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 hypericin potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 isoniazid pyruvate potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 isothymol inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 ivermectin inhibition of the ACE2 enzyme; potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 menthol potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 MLN-4760 inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 additional information inhibitors of SARS-CoV-2:ACE2 binding Homo sapiens
3.4.17.23 naringin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 neoandrographolide inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 Nitrofurantoin potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 orientin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 paritaprevir inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 piceatannol inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 pseudojervine inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 quercetin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 quercetin-3-O-galatosyl-rhamnosyl-glucoside inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 raspberry ketone potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 rutin inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 rutin DAB10 inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 saikosaponin A inhibition of the ACE2 enzyme Homo sapiens
3.4.17.23 spinochrome A inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
3.4.17.23 thymoquinone potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
3.4.17.23 vitexin inhibition of the ACE2 enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens Q9BYF1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 oral mucosa
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.17.23 physiological function SARS-CoV-2 binds to the angiotensin converting enzyme 2 (ACE2) receptor of the host cells through the viral surface spike glycoprotein (S-protein). ACE2 is expressed in the oral mucosa and can therefore constitute an essential route for entry of SARS-CoV-2 into hosts through the tongue and lung epithelial cells Homo sapiens