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Literature summary extracted from

  • Berger, R.S.; Ellmann, L.; Reinders, J.; Kreutz, M.; Stempfl, T.; Oefner, P.J.; Dettmer, K.
    Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations (2019), Sci. Rep., 9, 7436 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.1.99.39 Homo sapiens Q8N465
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.99.39 HT-1080 cell
-
 Homo sapiens
-
1.1.99.39 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.99.39 (R)-2-hydroxyglutarate + phenazine methosulfate
-
 Homo sapiens 2-oxoglutarate + reduced phenazine methosulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.99.39 D-2-hydroxyglutarate dehydrogenase
-
 Homo sapiens
1.1.99.39 D2HDH
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.99.39 7.6
-
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.99.39 Homo sapiens expression of the enzyme is upregulated in the presence of high endogenous concentrations of (S)-2-hydroxyglutarate up