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Literature summary extracted from

  • Khan, R.; Zeb, A.; Choi, K.; Lee, G.; Lee, K.; Lee, S.
    Biochemical and structural insights concerning triclosan resistance in a novel YX7K type enoyl-acyl carrier protein reductase from soil metagenome (2019), Sci. Rep., 9, 15401 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.9 homology modeling of structure uncultured bacterium

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.9 A128V mutation elevates triclosan resistance uncultured bacterium

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 triclosan triclosan may occupy the active site of FabI2 and form stable interactions with active catalytic residues. Mild resistance (20 microg/ml minimum inhibitory concentration) of FabI2 to triclosan is confined to the relatively less bulky side chain of A128. Substitution of A128 in FabI2 with valine elevates triclosan resistance uncultured bacterium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.9 0.0138
-
 crotonoyl-CoA pH 7, 25°C uncultured bacterium
1.3.1.9 0.0182
-
 NADH pH 7, 25°C uncultured bacterium

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 uncultured bacterium A0A1C9H9U9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonoyl-CoA + NADH + H+
-
 uncultured bacterium butanoyl-CoA + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 FabI2
-
 uncultured bacterium
1.3.1.9 OsmC
-
 uncultured bacterium

General Information

EC Number General Information Comment Organism
1.3.1.9 metabolism FabI2 possesses a YX7K type catalytic domain uncultured bacterium