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Literature summary extracted from

  • Spillier, Q.; Ravez, S.; Unterlass, J.; Corbet, C.; Degavre, C.; Feron, O.; Frederick, R.
    Structure-activity relationships (SARs) of alpha-ketothioamides as inhibitors of phosphoglycerate dehydrogenase (PHGDH) (2020), Pharmaceuticals, 13, 20 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.95 1-(2,4-dichlorophenyl)-2-morpholino-2-thioxoethan-1-one
-
 Homo sapiens
1.1.1.95 1-(4-chlorophenyl)-2-morpholino-2-thioxoethan-1-one
-
 Homo sapiens
1.1.1.95 2-(4-methylpiperidin-1-yl)-1-phenyl-2-thioxoethan-1-one
-
 Homo sapiens
1.1.1.95 2-morpholino-1-phenyl-2-thioxoethan-1-one
-
 Homo sapiens
1.1.1.95 morpholino(phenyl)methanethione
-
 Homo sapiens
1.1.1.95 N-morpholinobenzenesulfonamide
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.95 0.0304
-
 NAD+ pH 8.5, temperature not specified in the publication Homo sapiens
1.1.1.95 0.294
-
 3-phospho-D-glycerate pH 8.5, temperature not specified in the publication Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.95 Homo sapiens O43175
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.95
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.95 3-phospho-D-glycerate + NAD+
-
 Homo sapiens 3-phosphooxypyruvate + NADH + H+
-
 r
1.1.1.95 3-phosphooxypyruvate + NADH + H+
-
 Homo sapiens 3-phospho-D-glycerate + NAD+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.95 Phgdh
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.95 NAD+
-
 Homo sapiens
1.1.1.95 NADH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.95 0.0203
-
 pH 8.5, temperature not specified in the publication Homo sapiens 1-(4-chlorophenyl)-2-morpholino-2-thioxoethan-1-one
1.1.1.95 0.077
-
 pH 8.5, temperature not specified in the publication Homo sapiens 1-(2,4-dichlorophenyl)-2-morpholino-2-thioxoethan-1-one
1.1.1.95 0.0851
-
 pH 8.5, temperature not specified in the publication Homo sapiens 2-(4-methylpiperidin-1-yl)-1-phenyl-2-thioxoethan-1-one
1.1.1.95 0.0921
-
 pH 8.5, temperature not specified in the publication Homo sapiens N-morpholinobenzenesulfonamide
1.1.1.95 0.106
-
 pH 8.5, temperature not specified in the publication Homo sapiens morpholino(phenyl)methanethione
1.1.1.95 0.111
-
 pH 8.5, temperature not specified in the publication Homo sapiens 2-morpholino-1-phenyl-2-thioxoethan-1-one

General Information

EC Number General Information Comment Organism
1.1.1.95 metabolism the enzyme catalyzes the rate limiting step in serine biosynthesis pathway Homo sapiens