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Literature summary extracted from

  • Yan, G.; Zhu, B.R.; Tian, F.L.; Hui, X.; Li, H.; Li, Y.M.; Gao, W.Y.
    Inhibitory activity of plant essential oils against E. coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase (2019), Molecules, 24, 2518 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.267 additional information no effect by 0.5% DMSO on enzyme activity Escherichia coli

Application

EC Number Application Comment Organism
1.1.1.267 additional information the enzyme is a target for development of antibacterial drugs, determination of the antimicrobial activities of various essential oils against different microbials Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.267 carvacrol 55.6% inhibition of DXR Escherichia coli
1.1.1.267 carveol 23.2% inhibition of DXR Escherichia coli
1.1.1.267 eugenol 68.3% inhibition of DXR Escherichia coli
1.1.1.267 fosmidomycin
-
Escherichia coli
1.1.1.267 FR900098
-
Escherichia coli
1.1.1.267 gallocatechin gallate strong inhibition of DXR, isolated from Camellia sinenesis Escherichia coli
1.1.1.267 linalool 22.7% inhibition of DXR Escherichia coli
1.1.1.267 additional information determination of the antimicrobial activities of various essential oils against different microbials using 35 plant essential oils (EOs), which have long been recognized for their antimicrobial properties. Essential oils of Zanbthoxylum bungeanum (ZB), Schizonepetae tenuifoliae (ST), Thymus quinquecostatus (TQ), Origanum vulgare (OV), and Eugenia caryophyllata (EC) display weak to medium inhibitory activity against DXR, with IC50 values of 0.078 mg/ml, 0.065 mg/ml, 0.059 mg/ml, 0.048 mg/ml, and 0.037 mg/ml, respectively. Dry roots or dry fruits are used for extraction. Cercis siliquastrum leaf extract strongly inhibits enzyme DXR. No effect by 0.5% DMSO on enzyme activity Escherichia coli
1.1.1.267 theaflavin-3,3'-digallate strong inhibition of DXR, isolated from Camellia sinenesis Escherichia coli
1.1.1.267 Thymol 26.5% inhibition of DXR Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.267 Mg2+ the enzyme requires the presence of a divalent metal ion for activity Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Escherichia coli
-
2-C-methyl-D-erythritol 4-phosphate + NADP+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.267 Escherichia coli P45568
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
Escherichia coli 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.267 DXR
-
Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.267 30
-
assay at Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.267 7.4
-
assay at Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.267 NADP+
-
Escherichia coli
1.1.1.267 NADPH
-
Escherichia coli

General Information

EC Number General Information Comment Organism
1.1.1.267 metabolism rate-limiting enzyme in the 2-methyl-D-erythritol-4-phosphate (MEP) terpenoid biosynthetic pathway catalyzing the second step Escherichia coli