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Literature summary extracted from

  • Gent, R.; du Toit, T.; Swart, A.C.
    11alpha-Hydroxyprogesterone, a potent 11alpha-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5alpha-reductase and cytochrome P450 17alpha-hydroxylase/17,20-lyase to produce C11alpha-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro (2019), J. Steroid Biochem. Mol. Biol., 191, 105369 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.22 expression in HEK-293 cell Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens P18405 isoform SRD5A1
-
1.3.1.22 Homo sapiens P31213 isoform SRD5A2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 LNCaP cell
-
 Homo sapiens
-
1.3.1.22 PC-3 cell
-
 Homo sapiens
-
1.3.1.22 prostate gland cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 11alpha-hydroxyprogesterone + NADPH + H+
-
 Homo sapiens 11alpha-hydroxydihydroprogesterone + NADP+
-
 ?
1.3.1.22 11beta,17alpha-dihydroxyprogesterone + NADPH + H+
-
 Homo sapiens 11beta,17alpha-hydroxydihydroprogesterone + NADP+
-
 ?
1.3.1.22 11beta-hydroxyprogesterone + NADPH + H+
-
 Homo sapiens 11beta-hydroxydihydroprogesterone + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 SRD5A1
-
 Homo sapiens
1.3.1.22 SRD5A2
-
 Homo sapiens