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Literature summary extracted from

  • Appanna, N.; Gibson, H.; Gangitano, E.; Dempster, N.J.; Morris, K.; George, S.; Arvaniti, A.; Gathercole, L.L.; Keevil, B.; Penning, T.M.; Storbeck, K.H.; Tomlinson, J.W.; Nikolaou, N.
    Differential activity and expression of human 5beta-reductase (AKR1D1) splice variants (2021), J. Mol. Endocrinol., 66, 181-194 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.3 expression of splice variant AKR1D1 in HEK-293 cell Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.3 Homo sapiens P51857
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.3 liver splice variants AKR1D1-002 and AKR1D1-001 are expressed in liver Homo sapiens
-
1.3.1.3 testis only splice variant AKR1D1-006 is expressed in testis Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.3 dexamethasone + NADPH + H+ substrate of splice variant AKR1D1-002 Homo sapiens ? + NADP+
-
 ?
1.3.1.3 additional information splice variant AKR1D1-002 efficiently metabolizes glucocorticoids and androgens and decreases receptor activation. Variants AKR1D1-001 and AKR1D1-006 poorly metabolize dexamethasone, but do not metabolize cortisol, prednisolone, testosterone or androstenedione Homo sapiens ?
-
-
1.3.1.3 prednisolone + NADPH + H+ substrate of splice variant AKR1D1-002 Homo sapiens ? + NADP+
-
 ?
1.3.1.3 testosterone + NADPH + H+ substrate of splice variant AKR1D1-002 Homo sapiens (5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
-
 ?

Expression

EC Number Organism Comment Expression
1.3.1.3 Homo sapiens treatment of cells with proteasomal inhibitor, MG-132 increases expression of splice variants AKR1D1-001 and AKR1D1-006 up