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Literature summary extracted from

  • Khan, S.; Somvanshi, P.; Bhardwaj, T.; Mandal, R.K.; Dar, S.A.; Wahid, M.; Jawed, A.; Lohani, M.; Khan, M.; Areeshi, M.Y.; Haque, S.
    Aspartate-beta-semialdeyhyde dehydrogenase as a potential therapeutic target of Mycobacterium tuberculosis H37Rv Evidence from in silico elementary mode analysis of biological network model (2018), J. Cell. Biochem., 119, 2832-2842 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.11 gene asd, phylogenetic analysis Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.11 curcumin
-
 Mycobacterium tuberculosis
1.2.1.11 huperzine A
-
 Mycobacterium tuberculosis
1.2.1.11 additional information molecular docking and simulation studies of the priority target, enzyme ASD, reveals the therapeutic potential of the ASD inhibitors based on selected natural products (huperzine A, rosmarinic acid, and curcumin), overview Mycobacterium tuberculosis
1.2.1.11 rosmarinic acid
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+ Mycobacterium tuberculosis
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+ Mycobacterium tuberculosis H37Rv
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+ Mycobacterium tuberculosis ATCC 25618
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Mycobacterium tuberculosis P9WNX5
-
-
1.2.1.11 Mycobacterium tuberculosis ATCC 25618 P9WNX5
-
-
1.2.1.11 Mycobacterium tuberculosis H37Rv P9WNX5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Mycobacterium tuberculosis L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Mycobacterium tuberculosis H37Rv L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Mycobacterium tuberculosis ATCC 25618 L-4-aspartyl phosphate + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.2.1.11 ASADH
-
 Mycobacterium tuberculosis
1.2.1.11 Asd
-
 Mycobacterium tuberculosis
1.2.1.11 aspartate-beta-semialdeyhyde dehydrogenase
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.11 NADP+
-
 Mycobacterium tuberculosis
1.2.1.11 NADPH
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.2.1.11 metabolism mathematical modeling of the lysine metabolism in Mycobacterium tuberculosis strain H37Rv involving the enzyme, overview Mycobacterium tuberculosis