EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.5.1.2 | PYCR1 complexed with N-formyl-L-proline, inhibitor binding is accompanied by conformational changes in the active site, including the translation of an alpha-helix by 1 A | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.2 | cyclopentanecarboxylate | - |
Homo sapiens | |
1.5.1.2 | L-proline | - |
Homo sapiens | |
1.5.1.2 | L-tetrahydro-2-furoic acid | - |
Homo sapiens | |
1.5.1.2 | L-thiazolidine-2-carboxylate | - |
Homo sapiens | |
1.5.1.2 | L-thiazolidine-4-carboxylate | - |
Homo sapiens | |
1.5.1.2 | N-formyl-L-proline | competitive. Compound phenocopies the PYCR1 knockdown in MCF10A H-RASV12 breast cancer cells by inhibiting de novo proline biosynthesis and impairing spheroidal growth | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.2 | Homo sapiens | P32322 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.2 | 1-pyrroline-5-carboxylate + NADH + H+ | - |
Homo sapiens | L-proline + NAD+ | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.5.1.2 | 0.1 | - |
pH 7.8, temperature not specified in the publication | Homo sapiens | N-formyl-L-proline | |
1.5.1.2 | 0.44 | - |
pH 7.8, temperature not specified in the publication | Homo sapiens | L-thiazolidine-2-carboxylate | |
1.5.1.2 | 0.6 | - |
pH 7.8, temperature not specified in the publication | Homo sapiens | L-thiazolidine-4-carboxylate | |
1.5.1.2 | 1.19 | - |
pH 7.8, temperature not specified in the publication | Homo sapiens | cyclopentanecarboxylate | |
1.5.1.2 | 1.72 | - |
pH 7.8, temperature not specified in the publication | Homo sapiens | L-proline | |
1.5.1.2 | 2.25 | - |
pH 7.8, temperature not specified in the publication | Homo sapiens | L-tetrahydro-2-furoic acid |