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Literature summary extracted from
- Role of rare earth elements in methanol oxidation (2019), Curr. Opin. Chem. Biol., 49, 39-44 .
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.2.10 | 0.0008 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Eu3+, Lu3+ | Methylacidiphilum fumariolicum |  |
| 1.1.2.10 | 0.0008 | - |
methanol | pH and temperature not specified in the publication, lanthanide: La3+, Ce3+, Pr3+, Nd3+ | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | 0.0009 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Eu3+ | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | 0.0013 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Eu3+, La3+ | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | 0.029 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Ce3+ | Bradyrhizobium sp. | |
| 1.1.2.10 | 0.029 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Nd3+ | Methylorubrum extorquens | |
| 1.1.2.10 | 0.039 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Ce3+ | Methylomonas sp. LW13 | |
| 1.1.2.10 | 0.044 | - |
methanol | pH and temperature not specified in the publication, lanthanide: La3+ | Methylorubrum extorquens | |
| 1.1.2.10 | 0.055 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Ce3+ | Methylotenera mobilis | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.2.10 | periplasm | - |
Bradyrhizobium sp. | - |
- |
| 1.1.2.10 | periplasm | - |
Methylotenera mobilis | - |
- |
| 1.1.2.10 | periplasm | - |
Methylacidiphilum fumariolicum | - |
- |
| 1.1.2.10 | periplasm | - |
Methylomonas sp. LW13 | - |
- |
| 1.1.2.10 | periplasm | - |
Methylorubrum extorquens | - |
- |
| 1.1.2.10 | periplasm | - |
Methylobacterium aquaticum | - |
- |
| 1.1.2.10 | periplasm | - |
Methylotuvimicrobium buryatense | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.2.10 | Ce3+ | lanthanide-dependent enzyme | Bradyrhizobium sp. | |
| 1.1.2.10 | Ce3+ | lanthanide-dependent enzyme | Methylotenera mobilis | |
| 1.1.2.10 | Ce3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | Ce3+ | lanthanide-dependent enzyme | Methylomonas sp. LW13 | |
| 1.1.2.10 | Eu3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | La3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | La3+ | lanthanide-dependent enzyme | Methylorubrum extorquens | |
| 1.1.2.10 | Lu3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | Nd3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | Nd3+ | lanthanide-dependent enzyme | Methylorubrum extorquens | |
| 1.1.2.10 | Pr3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.2.10 | Bradyrhizobium sp. | - |
- |
- |
| 1.1.2.10 | Methylacidiphilum fumariolicum | - |
- |
- |
| 1.1.2.10 | Methylacidiphilum fumariolicum SolV | - |
- |
- |
| 1.1.2.10 | Methylobacterium aquaticum | A0A0C6F7V8 | - |
- |
| 1.1.2.10 | Methylobacterium aquaticum 22A | A0A0C6F7V8 | - |
- |
| 1.1.2.10 | Methylomonas sp. LW13 | - |
- |
- |
| 1.1.2.10 | Methylorubrum extorquens | C5B120 | - |
- |
| 1.1.2.10 | Methylotenera mobilis | - |
- |
- |
| 1.1.2.10 | Methylotenera mobilis JLW8 | - |
- |
- |
| 1.1.2.10 | Methylotuvimicrobium buryatense | A0A3F2YLY8 | - |
- |
| 1.1.2.10 | Methylotuvimicrobium buryatense 5G | A0A3F2YLY8 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Bradyrhizobium sp. | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylotenera mobilis | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylacidiphilum fumariolicum | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylomonas sp. LW13 | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylorubrum extorquens | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylobacterium aquaticum | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylotuvimicrobium buryatense | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylacidiphilum fumariolicum SolV | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylobacterium aquaticum 22A | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylotuvimicrobium buryatense 5G | formaldehyde + reduced phenazine methosulfate | - |
? | |
| 1.1.2.10 | methanol + phenazine methosulfate | - |
Methylotenera mobilis JLW8 | formaldehyde + reduced phenazine methosulfate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.2.10 | homodimer | - |
Bradyrhizobium sp. |
| 1.1.2.10 | homodimer | - |
Methylotenera mobilis |
| 1.1.2.10 | homodimer | - |
Methylacidiphilum fumariolicum |
| 1.1.2.10 | homodimer | - |
Methylomonas sp. LW13 |
| 1.1.2.10 | homodimer | - |
Methylorubrum extorquens |
| 1.1.2.10 | homodimer | - |
Methylobacterium aquaticum |
| 1.1.2.10 | homodimer | - |
Methylotuvimicrobium buryatense |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.2.10 | XoxF | - |
Bradyrhizobium sp. |
| 1.1.2.10 | XoxF | - |
Methylacidiphilum fumariolicum |
| 1.1.2.10 | XoxF | - |
Methylotuvimicrobium buryatense |
| 1.1.2.10 | xoxF1 | - |
Methylorubrum extorquens |
| 1.1.2.10 | XoxF4-1 | - |
Methylotenera mobilis |
| 1.1.2.10 | XoxF4-2 | - |
Methylotenera mobilis |
| 1.1.2.10 | XoxF5 | - |
Methylomonas sp. LW13 |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.2.10 | 7 | - |
- |
Bradyrhizobium sp. |
| 1.1.2.10 | 7 | - |
- |
Methylotenera mobilis |
| 1.1.2.10 | 7 | - |
- |
Methylacidiphilum fumariolicum |
| 1.1.2.10 | 7 | - |
- |
Methylomonas sp. LW13 |
| 1.1.2.10 | 7 | - |
- |
Methylorubrum extorquens |
| 1.1.2.10 | 7 | - |
- |
Methylobacterium aquaticum |
| 1.1.2.10 | 7 | - |
- |
Methylotuvimicrobium buryatense |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.2.10 | pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Bradyrhizobium sp. | |
| 1.1.2.10 | pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylotenera mobilis | |
| 1.1.2.10 | pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylacidiphilum fumariolicum | |
| 1.1.2.10 | pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylomonas sp. LW13 | |
| 1.1.2.10 | pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylorubrum extorquens | |
| 1.1.2.10 | pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylobacterium aquaticum | |
| 1.1.2.10 | pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylotuvimicrobium buryatense | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.1.2.10 | Methylorubrum extorquens | overexpression of xoxF at higher calcium concentrations compared to lanthanides | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.2.10 | malfunction | xoxF is required for the expression of mxaF in Methylobacterium aquaticum 22A, since xoxF deletion mutants are not able to grow in the presence of calcium | Methylobacterium aquaticum |
| 1.1.2.10 | metabolism | xoxF is required for the expression of mxaF in Methylobacterium aquaticum 22A, since xoxF deletion mutants are not able to grow in the presence of calcium | Methylobacterium aquaticum |
| 1.1.2.10 | metabolism | XoxF is the preferred enzyme for methanol oxidation, even when calcium is present in 100fold higher concentrations than lanthanide | Methylotuvimicrobium buryatense |
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