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Literature summary extracted from

  • Zhang, S.; Mo, J.; Wang, Y.; Ni, C.; Li, X.; Zhu, Q.; Ge, R.S.
    Endocrine disruptors of inhibiting testicular 3beta-hydroxysteroid dehydrogenase (2019), Chem. Biol. Interact., 303, 90-97 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 +/-gossypol potent, competitive Homo sapiens
1.1.1.145 6-hydroxyflavone very potent, competitive Homo sapiens
1.1.1.145 Biochanin A very potent Homo sapiens
1.1.1.145 bisphenol A potent, competitive Homo sapiens
1.1.1.145 daidzein very potent Homo sapiens
1.1.1.145 etomidate very potent, competitive Homo sapiens
1.1.1.145 formononetin potent Homo sapiens
1.1.1.145 genistein very potent, competitive Homo sapiens
1.1.1.145 ketoconazole very potent Homo sapiens
1.1.1.145 medroxyprogesterone potent Homo sapiens
1.1.1.145 methoxychlor moderate, noncompetitive Homo sapiens
1.1.1.145 myricetin moderate Homo sapiens
1.1.1.145 quercetin potent Homo sapiens
1.1.1.145 resveratrol potent, competitive Homo sapiens
1.1.1.145 tributyltin potent, competitive Homo sapiens
1.1.1.145 Triphenyltin potent, competitive Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.145 0.047
-
 dehydroepiandrosterone pH and temperature not specified in the publication Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.145 mitochondrion
-
 Homo sapiens 5739
-
1.1.1.145 smooth endoplasmic reticulum membrane-bound Homo sapiens 5790
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Homo sapiens P26439
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 testis isoenzyme HSD3B2 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+
-
 Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.145 3beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.145 HSD3B2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.145 metabolism the enzyme is responsible for intermediate steroidogenic reaction for the synthesis of androgens, estrogens, progestins, glucocorticoids, and mineralocorticoids in the adrenal cortex, gonads, placenta, and a variety of peripheral target tissues Homo sapiens