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Literature summary extracted from

  • Chang, Z.; Dai, W.; Mao, Y.; Cui, Z.; Wang, Z.; Chen, T.
    Engineering Corynebacterium glutamicum for the efficient production of 3-hydroxypropionic acid from a mixture of glucose and acetate via the malonyl-CoA pathway (2020), Catalysts, 10, 203 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.75 expressed in Corynebacterium glutamicum strain ATCC13032 Chloroflexus aurantiacus

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.75 N940V/K1106W/S1114R the mutations increase the activity of C-terminal of the enzyme by 5.54fold as compared to the wild type Chloroflexus aurantiacus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.75 malonate semialdehyde + NADPH + H+ Chloroflexus aurantiacus
-
 3-hydroxypropionic acid + NADP+
-
 ?
1.2.1.75 malonyl-CoA + NADPH + H+ Chloroflexus aurantiacus
-
 malonate semialdehyde + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.75 Chloroflexus aurantiacus Q6QQP7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.75 malonate semialdehyde + NADPH + H+
-
 Chloroflexus aurantiacus 3-hydroxypropionic acid + NADP+
-
 ?
1.2.1.75 malonyl-CoA + NADPH + H+
-
 Chloroflexus aurantiacus malonate semialdehyde + CoA + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.75 malonyl-CoA reductase
-
 Chloroflexus aurantiacus
1.2.1.75 MCR
-
 Chloroflexus aurantiacus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.75 NADPH
-
 Chloroflexus aurantiacus