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Literature summary extracted from

  • Cheng, Z.; Wang, R.; Shen, J.; Yang, Z.; Chen, Y.
    Cloning, characterization, and expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene from Dioscorea zingiberensis (2019), Biol. Plant., 63, 262-267 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.267 gene dxr, DNA and amino acid sequence determination and analysis, sequence comparisons with other plant enzymes, quantitative real-time PCR enzyme expression analysis Dioscorea zingiberensis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.267 chloroplast the sequence of DzDXR has a putative plastid transit peptide at the N-terminal region Dioscorea zingiberensis 9507
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Dioscorea zingiberensis
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 2-C-methyl-D-erythritol 4-phosphate + NADP+
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.267 Dioscorea zingiberensis A0A1P8JPV2
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.267 leaf young and mature Dioscorea zingiberensis
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1.1.1.267 additional information during the growth period of Dioscorea zingiberensis, the expression of DzDXR is significantly high in leaves and very low in tubers, and the highest expression is observed in mature leaves in summer, quantitative real-time PCR enzyme expression analysis Dioscorea zingiberensis
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1.1.1.267 tuber young and old Dioscorea zingiberensis
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
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 Dioscorea zingiberensis 2-C-methyl-D-erythritol 4-phosphate + NADP+
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.267 DXR
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 Dioscorea zingiberensis
1.1.1.267 DzDXR
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 Dioscorea zingiberensis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.267 NADP+
-
 Dioscorea zingiberensis
1.1.1.267 NADPH
-
 Dioscorea zingiberensis

General Information

EC Number General Information Comment Organism
1.1.1.267 evolution Dioscorea zingiberensis DzDXR is highly homologous to other plant DXRs, especially to those in monocotyledons Dioscorea zingiberensis
1.1.1.267 metabolism 1-deoxy-D-xylulose 5-phosphate-reductoisomerase (DXR,) is the key enzyme in the plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. In contrast to the DzDXR transcription, diosgenin is present predominantly in tubers and in minute quantities in leaves. Because diosgenin is very likely formed mainly in the cytosol of mature leaf cells of Dioscorea zingiberensis and the plastidic IPP and DMAPP produced by the MEP pathway can be transported into the cytosol, the consistently high expression of DzDXR detected in mature leaf of Dioscorea zingiberensis implies that the MEP pathway might play a significant role in diosgenin biosynthesis Dioscorea zingiberensis