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Literature summary extracted from

  • Fujimoto, S.; Mizutani, N.; Mizota, C.; Tamaki, N.
    The level of beta-alanine aminotransferase activity in regenerating and differentiating rat liver (1986), Biochim. Biophys. Acta, 882, 106-112 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.120 1
-
 2-oxoglutarate pH 8.8, 37°C Rattus norvegicus
2.6.1.120 6.3
-
 beta-Alanine pH 8.8, 37°C Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.120 105000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.120 5-aminopentanoate + 2-oxoglutarate Rattus norvegicus
-
 L-glutamate + 5-oxopentanoate
-
 ?
2.6.1.120 6-aminohexanoate + 2-oxoglutarate Rattus norvegicus
-
 L-glutamate + 6-oxohexanoate
-
 ?
2.6.1.120 beta-alanine + 2-oxoglutarate Rattus norvegicus
-
 3-oxopropanoate + L-glutamate
-
 ?
2.6.1.120 L-2-aminoisobutanoate + 2-oxoglutarate Rattus norvegicus
-
 2-oxoisobutanoate + L-glutamate
-
 ?
2.6.1.120 additional information Rattus norvegicus 4-aminobutanoate is also accepted as amino donor, reaction of EC 2.6.1.19. No donors: glycine, alanine, taurine, ornithine, spermine, spermidine, putrescine. Very poor acceptors: pyruvate, glyoxylate, oxaloacetate, phenylpyruvate ?
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.120 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.120 liver activity in regenerating rat liver is lower than that in control rat liver, activity is low in newborn rat liver and increases about 5fold, reaching the level observed in adult rat liver Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.120 0.408
-
 pH 8.8, 37°C Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.120 5-aminopentanoate + 2-oxoglutarate
-
 Rattus norvegicus L-glutamate + 5-oxopentanoate
-
 ?
2.6.1.120 6-aminohexanoate + 2-oxoglutarate
-
 Rattus norvegicus L-glutamate + 6-oxohexanoate
-
 ?
2.6.1.120 beta-alanine + 2-oxoglutarate
-
 Rattus norvegicus 3-oxopropanoate + L-glutamate
-
 ?
2.6.1.120 L-2-aminoisobutanoate + 2-oxoglutarate
-
 Rattus norvegicus 2-oxoisobutanoate + L-glutamate
-
 ?
2.6.1.120 additional information 4-aminobutanoate is also accepted as amino donor, reaction of EC 2.6.1.19. No donors: glycine, alanine, taurine, ornithine, spermine, spermidine, putrescine. Very poor acceptors: pyruvate, glyoxylate, oxaloacetate, phenylpyruvate Rattus norvegicus ?
-
-

Subunits

EC Number Subunits Comment Organism
2.6.1.120 dimer 2 * 56000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.120 9 9.2
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.6.1.120 physiological function the liver enzyme transaminates from beta-alanine to 2-oxoglutaric acid, while the brain enzyme transaminates from gamma-aminobutyric acid, reaction of EC 2.6.1.19. beta-Alanine aminotransferase activity in regenerating rat liver is lower than that in control rat liver Rattus norvegicus