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Literature summary extracted from

  • Katane, M.; Kuwabara, H.; Nakayama, K.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Homma, H.
    Rat D-aspartate oxidase is more similar to the human enzyme than the mouse enzyme (2018), Biochim. Biophys. Acta, 1866, 806-812 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.1 expression in Escherichia coli Mus musculus
1.4.3.1 expression in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.1 5-aminonicotinic acid directly binds to the active site Mus musculus
1.4.3.1 5-aminonicotinic acid directly binds to the active site Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.1 146000
-
 PAGE Mus musculus
1.4.3.1 146000
-
 PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.1 Mus musculus Q0E9Q7
-
-
1.4.3.1 Rattus norvegicus D3ZDM7
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.1 0.53
-
 substrate D-glutamate, pH 8.3, 37°C Mus musculus
1.4.3.1 1.77
-
 substrate D-glutamate, pH 8.3, 37°C Rattus norvegicus
1.4.3.1 11.7
-
 substrate D-aspartate, pH 8.3, 37°C Mus musculus
1.4.3.1 51.7
-
 substrate D-aspartate, pH 8.3, 37°C Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.1 D-aspartate + H2O + O2
-
 Mus musculus oxaloacetate + H2O2 + NH3
-
 ?
1.4.3.1 D-aspartate + H2O + O2
-
 Rattus norvegicus oxaloacetate + H2O2 + NH3
-
 ?
1.4.3.1 D-glutamate + H2O + O2
-
 Mus musculus 2-oxoglutarate + NH3 + H2O2
-
 ?
1.4.3.1 D-glutamate + H2O + O2
-
 Rattus norvegicus 2-oxoglutarate + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.1 tetramer 4 * 41700, calculated from sequence, His-tagged protein Mus musculus
1.4.3.1 tetramer 4 * 41700, calculated from sequence, His-tagged protein Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.1 45
-
-
 Mus musculus
1.4.3.1 45
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.4.3.1 8.3 12.5
-
 Rattus norvegicus
1.4.3.1 8.3 11
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.1 FAD
-
 Mus musculus
1.4.3.1 FAD Kd value 0.128 microM Rattus norvegicus