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Literature summary extracted from

  • Yamamoto, K.; Mohri, S.; Furuya, S.
    D-3-phosphoglycerate dehydrogenase from the silkworm Bombyx mori Identification, functional characterization, and expression (2021), Arch. Insect Biochem. Physiol., 106, e21751 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.95 expression in Escherichia coli Bombyx mori

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.95 0.027
-
 3-phosphooxypyruvate pH and temperature not specified in the publication Bombyx mori

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.95 Bombyx mori H9JRZ9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.95
-
 Bombyx mori

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.95 midgut high expression levels of bmphgdh messenger RNA (mRNA) Bombyx mori
-
1.1.1.95 silk gland high expression levels of bmphgdh messenger RNA (mRNA) Bombyx mori
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.95 3-phosphooxypyruvate + NADH + H+
-
 Bombyx mori 3-phospho-D-glycerate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.95 D-3-phosphoglycerate dehydrogenase
-
 Bombyx mori
1.1.1.95 Phgdh
-
 Bombyx mori

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.95 30
-
-
 Bombyx mori

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.1.1.95 20 50 at temperatures of 20-50°C, the activity of the enzyme is greater than 80% of maximal activity Bombyx mori

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.95 7
-
-
 Bombyx mori

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.95 4 9 pH 4.0: about 82% of maximal activity, pH 9.0: about 80% of maximal activity Bombyx mori

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.95 NADH no activity in presence of NADPH Bombyx mori

Expression

EC Number Organism Comment Expression
1.1.1.95 Bombyx mori a sericin-deficient silkworm strain displays reduced expression of bmphgdh mRNA down

General Information

EC Number General Information Comment Organism
1.1.1.95 physiological function key enzyme involved in the synthesis of L-serine. Might play a crucial role in the provision of L-serine in the larva of Bombyx mori Bombyx mori