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Literature summary extracted from

  • Arakawa, T.; Sato, Y.; Yamada, M.; Takabe, J.; Moriwaki, Y.; Masamura, N.; Kato, M.; Aoyagi, M.; Kamoi, T.; Terada, T.; Shimizu, K.; Tsuge, N.; Imai, S.; Fushinobu, S.
    Dissecting the stereocontrolled conversion of short-lived sulfenic acid by lachrymatory factor synthase (2020), ACS Catal., 10, 9-19 .
No PubMed abstract available

Protein Variants

EC Number Protein Variants Comment Organism
5.3.99.12 C107A the mutant exhibits 89.9% of wild type activity Allium cepa
5.3.99.12 E112Q the mutant exhibits 104% of wild type activity Allium cepa
5.3.99.12 E88A the mutant exhibits 0.585% of wild type activity Allium cepa
5.3.99.12 E88D the mutant exhibits 0.571% of wild type activity Allium cepa
5.3.99.12 E88Q the mutant exhibits 0.53% of wild type activity Allium cepa
5.3.99.12 F104A the mutant exhibits 2.18% of wild type activity Allium cepa
5.3.99.12 F104Y the mutant exhibits 21% of wild type activity Allium cepa
5.3.99.12 F84A the mutant exhibits 1.32% of wild type activity Allium cepa
5.3.99.12 L47A the mutant exhibits 52.8% of wild type activity Allium cepa
5.3.99.12 L54A the mutant exhibits 108% of wild type activity Allium cepa
5.3.99.12 M118A the mutant exhibits 85.5% of wild type activity Allium cepa
5.3.99.12 M143A the mutant exhibits 130% of wild type activity Allium cepa
5.3.99.12 M51A the mutant exhibits 102% of wild type activity Allium cepa
5.3.99.12 R71A/E88A the mutant exhibits 0.303% of wild type activity Allium cepa
5.3.99.12 R71K the mutant exhibits 55.8% of wild type activity Allium cepa
5.3.99.12 R71L the mutant exhibits 0.453% of wild type activity Allium cepa
5.3.99.12 T109A the mutant exhibits 110% of wild type activity Allium cepa
5.3.99.12 V73A the mutant exhibits 91.3% of wild type activity Allium cepa
5.3.99.12 W133A the mutant exhibits 3.86% of wild type activity Allium cepa
5.3.99.12 W155A the mutant exhibits 1.51% of wild type activity Allium cepa
5.3.99.12 Y102A the mutant exhibits 0.133% of wild type activity Allium cepa
5.3.99.12 Y102F the mutant exhibits 11.5% of wild type activity Allium cepa
5.3.99.12 Y114A the mutant exhibits 2.78% of wild type activity Allium cepa
5.3.99.12 Y114F the mutant exhibits 1.52% of wild type activity Allium cepa

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.12 1,2-propanediol
-
 Allium cepa
5.3.99.12 crotyl alcohol
-
 Allium cepa
5.3.99.12 additional information not inhibited by glycerol Allium cepa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.12 (E)-prop-1-en-1-SO-peroxol Allium cepa
-
 (Z)-propanethial oxide
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.12 Allium cepa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.12 (E)-prop-1-en-1-SO-peroxol
-
 Allium cepa (Z)-propanethial oxide
-
 ir

Synonyms

EC Number Synonyms Comment Organism
5.3.99.12 lachrymatory factor synthase
-
 Allium cepa
5.3.99.12 LFS
-
 Allium cepa