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Literature summary extracted from

  • Yan, Q.; Jiang, D.; Qian, L.; Zhang, Q.; Zhang, W.; Zhou, W.; Mi, K.; Guddat, L.; Yang, H.; Rao, Z.
    Structural insight into the activation of PknI kinase from M.xa0tuberculosis via dimerization of the extracellular sensor domain (2017), Structure, 25, 1286-1294.e4.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.1 additional information activation of PknI kinase from Mycobacteriumxa0tuberculosis via dimerization of the extracellular sensor domain Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 fusion proteins expressed in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.11.1 vapor diffusion method, crystal structures of PknI sensor domain (PknI_SD) monomer and dimer, as well as PknI kinase domain (PknI_KD) Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Mycobacterium tuberculosis P9WI69
-
-
2.7.11.1 Mycobacterium tuberculosis H37Rv P9WI69
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein simulated PknI_KJD dimerization activates kinase autophosphorylation activity Mycobacterium tuberculosis

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.1
-
 Mycobacterium tuberculosis

Subunits

EC Number Subunits Comment Organism
2.7.11.1 dimer PknI sensor domain (PknI_SD) adopts two conformations in solution: monomer and dimer Mycobacterium tuberculosis
2.7.11.1 monomer PknI sensor domain (PknI_SD) adopts two conformations in solution: monomer and dimer Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 PknI
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.7.11.1 physiological function the enzyme is required for regulating Mycobacterium tuberculosis growth within macrophage Mycobacterium tuberculosis