Literature summary extracted from

Chen, S.; Wang, X.; Ye, X.; Ma, D.; Chen, C.; Cai, J.; Fu, Y.; Cheng, X.; Chen, Y.; Gong, X.; Jin, J.
Identification of human UMP/CMP kinase 1 as doxorubicin binding target using protein microarray (2017), SLAS Discov., 22, 1007-1015 .

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.4.14	doxorubicin	binding of doxorubicin to the enzyme (CMPK1) activates the phosphorylation of CMP, dCMP, and UMP. Doxorubicin might bind to the nonactive site of CMPK1 and regulate its activity with magnesium	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.4.14	Homo sapiens	P30085	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.4.14	ATP + CMP	-	Homo sapiens	ADP + CDP	-	?
2.7.4.14	ATP + dCMP	-	Homo sapiens	ADP + dCDP	-	?
2.7.4.14	ATP + UMP	-	Homo sapiens	ADP + UDP	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.4.14	CMPK1	-	Homo sapiens
2.7.4.14	UMP/CMP kinase 1	-	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.7.4.14	37	-	assay at	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.7.4.14	7.5	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)