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Literature summary extracted from

  • Moitra, S.; Pawlowic, M.C.; Hsu, F.F.; Zhang, K.
    Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major (2019), Sci. Rep., 9, 7602 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 endoplasmic reticulum mainly located in the endoplasmic reticulum Leishmania major 5783
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + phosphocholine Leishmania major
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 diphosphate + CDP-choline
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Leishmania major Q4QDQ6
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + phosphocholine
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 Leishmania major diphosphate + CDP-choline
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 cholinephosphate cytidylyltransferase
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 Leishmania major
2.7.7.15 cpcT
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 Leishmania major
2.7.7.15 LmjF.18.1330
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 Leishmania major

General Information

EC Number General Information Comment Organism
2.7.7.15 malfunction without cholinephosphate cytidylyltransferase (CPCT), Leishmania major parasites cannot incorporate choline into phosphatidylcholine, yet the CPCT-null mutants contain similar levels of phosphatidylcholine and phosphatidylethanolamine as wild type parasites. Loss of CPCT does not affect the growth of parasites in complete medium or their virulence in mice. The results suggest that other mechanisms of phosphatidylcholine synthesis can compensate the loss of CPCT. CPCT-null parasites exhibit severe growth defects when ethanolamine and exogenous lipids became limited or when they are co-cultured with certain bacteria that are known to be members of sandfly midgut microbiota Leishmania major
2.7.7.15 metabolism the enzyme catalyzes the formation of CDP-choline, a key intermediate in the choline branch of the Kennedy pathway Leishmania major