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Literature summary extracted from

  • McKay, L.J.; Hatzenpichler, R.; Inskeep, W.P.; Fields, M.W.
    Occurrence and expression of novel methyl-coenzyme M reductase gene (mcrA) variants in hot spring sediments (2017), Sci. Rep., 7, 7252 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.4.1 Ni2+ contained in the coenzyme F430 Euryarchaeota
2.8.4.1 Ni2+ contained in the coenzyme F430 Candidatus Bathyarchaeota
2.8.4.1 Ni2+ contained in the coenzyme F430 Candidatus Verstraetearchaeota

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.4.1 methyl-CoM + CoB Euryarchaeota
-
 CoM-S-S-CoB + methane
-
 ?
2.8.4.1 methyl-CoM + CoB Candidatus Bathyarchaeota
-
 CoM-S-S-CoB + methane
-
 ?
2.8.4.1 methyl-CoM + CoB Candidatus Verstraetearchaeota
-
 CoM-S-S-CoB + methane
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.4.1 Candidatus Bathyarchaeota
-
 isolated in Yellowstone National Park (YNP, Wyoming, USA) from Washburn Hot Springs (WS) and Heart Lake Geyser Basin (HL)
-
2.8.4.1 Candidatus Verstraetearchaeota
-
 isolated in Yellowstone National Park (YNP, Wyoming, USA) from Washburn Hot Springs (WS) and Heart Lake Geyser Basin (HL)
-
2.8.4.1 Euryarchaeota
-
 isolated in Yellowstone National Park (YNP, Wyoming, USA) from Washburn Hot Springs (WS) and Heart Lake Geyser Basin (HL)
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.4.1 methyl-CoM + CoB
-
 Euryarchaeota CoM-S-S-CoB + methane
-
 ?
2.8.4.1 methyl-CoM + CoB
-
 Candidatus Bathyarchaeota CoM-S-S-CoB + methane
-
 ?
2.8.4.1 methyl-CoM + CoB
-
 Candidatus Verstraetearchaeota CoM-S-S-CoB + methane
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.4.1 mcrA gene name, encoding subunit A Euryarchaeota
2.8.4.1 mcrA gene name, encoding subunit A Candidatus Bathyarchaeota
2.8.4.1 mcrA gene name, encoding subunit A Candidatus Verstraetearchaeota
2.8.4.1 methyl-coenzyme M reductase
-
 Euryarchaeota
2.8.4.1 methyl-coenzyme M reductase
-
 Candidatus Bathyarchaeota
2.8.4.1 methyl-coenzyme M reductase
-
 Candidatus Verstraetearchaeota

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.4.1 F-430 coenzyme F430, rapid kinetic studies rule out methyl-Ni(III) and trap the MCRox1-silent intermediate. Identification of an MCRox1-like state, specifically a F430-Ni(III)-SCoM/CoBS- intermediate, from direct DFT calculations Euryarchaeota
2.8.4.1 F-430 coenzyme F430, rapid kinetic studies rule out methyl-Ni(III) and trap the MCRox1-silent intermediate. Identification of an MCRox1-like state, specifically a F430-Ni(III)-SCoM/CoBS- intermediate, from direct DFT calculations Candidatus Bathyarchaeota
2.8.4.1 F-430 coenzyme F430, rapid kinetic studies rule out methyl-Ni(III) and trap the MCRox1-silent intermediate. Identification of an MCRox1-like state, specifically a F430-Ni(III)-SCoM/CoBS- intermediate, from direct DFT calculations Candidatus Verstraetearchaeota

General Information

EC Number General Information Comment Organism
2.8.4.1 evolution the marker gene for anaerobic methane cycling (mcrA) is more widespread in the Archaea than previously thought. Small-subunit (SSU) rRNA gene analyses indicate that Bathyarchaeota are predominant in seven of ten sediment layers, while the Verstraetearchaeota and Euryarchaeota occur in lower relative abundance. Targeted amplification of mcrA genes suggests that diverse taxa contribute to alkane cycling in geothermal environments. Two deeply-branching mcrA clades related to Bathyarchaeota are identified, while highly abundant verstraetearchaeotal mcrA sequences are also recovered. SSU rRNA gene survey of Archaea and phylogenetic analysis and distribution, overview Euryarchaeota
2.8.4.1 evolution the marker gene for anaerobic methane cycling (mcrA) is more widespread in the Archaea than previously thought. Small-subunit (SSU) rRNA gene analyses indicate that Bathyarchaeota are predominant in seven of ten sediment layers, while the Verstraetearchaeota and Euryarchaeota occur in lower relative abundance. Targeted amplification of mcrA genes suggests that diverse taxa contribute to alkane cycling in geothermal environments. Two deeply-branching mcrA clades related to Bathyarchaeota are identified, while highly abundant verstraetearchaeotal mcrA sequences are also recovered. SSU rRNA gene survey of Archaea and phylogenetic analysis and distribution, overview Candidatus Bathyarchaeota
2.8.4.1 evolution the marker gene for anaerobic methane cycling (mcrA) is more widespread in the Archaea than previously thought. Small-subunit (SSU) rRNA gene analyses indicate that Bathyarchaeota are predominant in seven of ten sediment layers, while the Verstraetearchaeota and Euryarchaeota occur in lower relative abundance. Targeted amplification of mcrA genes suggests that diverse taxa contribute to alkane cycling in geothermal environments. Two deeply-branching mcrA clades related to Bathyarchaeota are identified, while highly abundant verstraetearchaeotal mcrA sequences are also recovered. SSU rRNA gene survey of Archaea and phylogenetic analysis and distribution, overview Candidatus Verstraetearchaeota
2.8.4.1 physiological function the enzyme is involved in anaerobic alkane cycling Euryarchaeota
2.8.4.1 physiological function the enzyme is involved in anaerobic alkane cycling Candidatus Bathyarchaeota
2.8.4.1 physiological function the enzyme is involved in anaerobic alkane cycling Candidatus Verstraetearchaeota