EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.184 | quercetin | - |
Equus caballus | |
1.1.1.184 | quercetin | - |
Homo sapiens | |
1.1.1.184 | quercetin | - |
Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.184 | cortisol + NADPH + H+ | Equus caballus | - |
20beta-dihydrocortisol + NADP+ | - |
? | |
1.1.1.184 | cortisol + NADPH + H+ | Homo sapiens | - |
20beta-dihydrocortisol + NADP+ | - |
? | |
1.1.1.184 | cortisol + NADPH + H+ | Mus musculus | - |
20beta-dihydrocortisol + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.184 | Equus caballus | - |
- |
- |
1.1.1.184 | Homo sapiens | P16152 | - |
- |
1.1.1.184 | Mus musculus | P48758 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.184 | adipose tissue | - |
Equus caballus | - |
1.1.1.184 | adipose tissue | - |
Homo sapiens | - |
1.1.1.184 | adipose tissue | - |
Mus musculus | - |
1.1.1.184 | gut | - |
Equus caballus | - |
1.1.1.184 | gut | - |
Mus musculus | - |
1.1.1.184 | kidney | - |
Equus caballus | - |
1.1.1.184 | kidney | - |
Mus musculus | - |
1.1.1.184 | liver | - |
Equus caballus | - |
1.1.1.184 | liver | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.184 | cortisol + NADPH + H+ | - |
Equus caballus | 20beta-dihydrocortisol + NADP+ | - |
? | |
1.1.1.184 | cortisol + NADPH + H+ | - |
Homo sapiens | 20beta-dihydrocortisol + NADP+ | - |
? | |
1.1.1.184 | cortisol + NADPH + H+ | - |
Mus musculus | 20beta-dihydrocortisol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.184 | carbonyl reductase 1 | - |
Equus caballus |
1.1.1.184 | carbonyl reductase 1 | - |
Homo sapiens |
1.1.1.184 | carbonyl reductase 1 | - |
Mus musculus |
1.1.1.184 | CBR1 | - |
Equus caballus |
1.1.1.184 | CBR1 | - |
Homo sapiens |
1.1.1.184 | CBR1 | - |
Mus musculus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.1.1.184 | Equus caballus | the enzyme is up-regulated in adipose tissue in obesity | up |
1.1.1.184 | Homo sapiens | the enzyme is up-regulated in adipose tissue in obesity | up |
1.1.1.184 | Mus musculus | the enzyme is up-regulated in adipose tissue in obesity | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.184 | malfunction | pharmacological inhibition of carbonyl reductase 1 in diet-induced obesity in mice results in more marked glucose intolerance with evidence for enhanced hepatic glucocorticoid receptor signaling | Mus musculus |
1.1.1.184 | metabolism | carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity | Equus caballus |
1.1.1.184 | metabolism | carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity | Homo sapiens |
1.1.1.184 | metabolism | carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity | Mus musculus |