Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yu, Y.; Hu, Z.; Dong, H.; Ma, J.; Wang, H.
    Xanthomonas campestris FabH is required for branched-chain fatty acid and DSF-family quorum sensing signal biosynthesis (2016), Sci. Rep., 6, 32811 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.300 Xanthomonas campestris pv. campestris Q4URQ0 cf. EC 2.3.1.180
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.300 11350
-
 substrate isobutanoyl-CoA, pH 7, temperature not specified in the publication Xanthomonas campestris pv. campestris
2.3.1.300 17350
-
 substrate isovaleryl-CoA, pH 7, temperature not specified in the publication Xanthomonas campestris pv. campestris

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.300 isobutanoyl-CoA + malonyl-[acyl-carrier protein]
-
 Xanthomonas campestris pv. campestris 5-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2
-
 ?
2.3.1.300 isovaleryl-CoA + malonyl-[acyl-carrier protein]
-
 Xanthomonas campestris pv. campestris ? + CoA + CO2
-
 ?
2.3.1.300 additional information FabH in addition uses acetyl-CoA, butanoyl-CoA, hexanoyl-CoA, octanoyl-CoA, or decanoyl-CoA as a primer as a primer to initiate fatty acid synthesis, reaction of EC 2.3.1.180, and also condenses short-chain acyl-ACPs with malonyl-ACP to produce longer acyl-ACPs Xanthomonas campestris pv. campestris ?
-
-

General Information

EC Number General Information Comment Organism
2.3.1.300 physiological function FabH is able to condense branched-chain acyl-CoAs with malonyl-ACP to initiate branched-chain fatty acid synthesis. The fabH gene is essential for growth of Xanthomonas campestris. It can be replaced with Escherichia coli fabH, and transgenic strains mutants fail to produce branched-chain fatty acids. Xanthomonas campestris FabH mutants lost the ability to produce cis-11-methyl-2-dodecenoic acid Xanthomonas campestris pv. campestris