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Literature summary extracted from

  • Chung, S.; Kim, I.H.; Lee, D.; Park, K.; Kim, J.Y.; Lee, Y.K.; Kim, E.J.; Lee, H.W.; Choi, J.S.; Son, G.H.; Sun, W.; Shin, K.S.; Kim, H.
    The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function (2016), Sci. Rep., 6, 23757 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.127 gene Itpka, quantitative reverse transcription-PCR enzyme expression analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.127 additional information generation of IP3K-A KO mice and electrophysiological properties of IP3K-A KO mice, overview. No significant differences in basic electrophysiological properties between groups, such as resting membrane potential and input resistance is found. But the input-output functions of CeL neurons are significantly attenuated along with a longer latency to the first spike in KO mice Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
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 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus C57BL/6N
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 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Mus musculus Q8R071
-
-
2.7.1.127 Mus musculus C57BL/6N Q8R071
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 amygdala IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. P3K-A is primarily expressed in neurons rather than glia in the amygdala. In the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons Mus musculus
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2.7.1.127 brain
-
 Mus musculus
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2.7.1.127 forebrain
-
 Mus musculus
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2.7.1.127 neuron in the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus C57BL/6N ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase A
-
 Mus musculus
2.7.1.127 IP3K-A
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.127 malfunction genetic abrogation of IP3K-A alters amygdala gene expression, particularly in genes involved in key intracellular signaling pathways and genes mediating fear- and anxiety-related behaviors. In agreement with the changes in amygdala gene expression profiles, IP3K-A knockout (KO) mice display more robust responses to aversive stimuli and spent less time in the open arms of the elevated plus maze, indicating high levels of innate fear and anxiety. Decreased excitatory and inhibitory postsynaptic current and reduced c-Fos immunoreactivity are found in the CeA of IP3K-A KO mice Mus musculus
2.7.1.127 physiological function inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is enriched in the brain and neurons that regulates intracellular calcium levels via signaling through the inositol trisphosphate receptor. IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. IP3K-A has a profound influence on the basal activities of fear- and anxiety-mediating amygdala circuitry. IP3K-A plays an important role in regulating affective states by modulating metabotropic receptor signaling pathways and neural activity in the amygdala Mus musculus