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Literature summary extracted from

  • Zhang, H.; Ishige, K.; Kornberg, A.
    A polyphosphate kinase (PPK2) widely conserved in bacteria (2002), Proc. Natl. Acad. Sci. USA, 99, 16678-16683 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.4.1 Polyphosphate stimulation Pseudomonas aeruginosa
2.7.4.34 Polyphosphate stimulation Pseudomonas aeruginosa

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.1
-
 Pseudomonas aeruginosa
2.7.4.34
-
 Pseudomonas aeruginosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.1 0.5
-
 ATP pH 7.2, 37°C Pseudomonas aeruginosa
2.7.4.34 0.68
-
 GTP pH 7.2, 37°C Pseudomonas aeruginosa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.1 Mg2+ preference for Mn2+ over Mg2+ Pseudomonas aeruginosa
2.7.4.1 Mn2+ preference for Mn2+ over Mg2+ Pseudomonas aeruginosa
2.7.4.34 Mg2+ preference for Mn2+ over Mg2+ Pseudomonas aeruginosa
2.7.4.34 Mn2+ preference for Mn2+ over Mg2+ Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.1 Pseudomonas aeruginosa Q9I6Z1 cf. EC 2.7.4.34
-
2.7.4.1 Pseudomonas aeruginosa DSM 22644 Q9I6Z1 cf. EC 2.7.4.34
-
2.7.4.34 Pseudomonas aeruginosa Q9I6Z1 cf. EC 2.7.4.1
-
2.7.4.34 Pseudomonas aeruginosa DSM 22644 Q9I6Z1 cf. EC 2.7.4.1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.1 ADP + (phosphate)n+1
-
 Pseudomonas aeruginosa ATP + (phosphate)n
-
 r
2.7.4.1 ADP + (phosphate)n+1
-
 Pseudomonas aeruginosa DSM 22644 ATP + (phosphate)n
-
 r
2.7.4.1 ATP + (phosphate)n
-
 Pseudomonas aeruginosa ADP + (phosphate)n+1
-
 r
2.7.4.1 ATP + (phosphate)n
-
 Pseudomonas aeruginosa DSM 22644 ADP + (phosphate)n+1
-
 r
2.7.4.1 additional information GTP (reaction of EC 2.7.4.34) and ATP are equally active in polyphosphate synthesis Pseudomonas aeruginosa ?
-
-
2.7.4.1 additional information GTP (reaction of EC 2.7.4.34) and ATP are equally active in polyphosphate synthesis Pseudomonas aeruginosa DSM 22644 ?
-
-
2.7.4.34 GDP + (phosphate)n+1 short polyphosphyate chains are preferred, enzyme displays processivity Pseudomonas aeruginosa GTP + (phosphate)n
-
 r
2.7.4.34 GDP + (phosphate)n+1 short polyphosphyate chains are preferred, enzyme displays processivity Pseudomonas aeruginosa DSM 22644 GTP + (phosphate)n
-
 r
2.7.4.34 GTP + (phosphate)n polyphosphate chains of 15-700 are all effective in synthesis, but P3 is not Pseudomonas aeruginosa GDP + (phosphate)n+1
-
 r
2.7.4.34 additional information the polyphosphate-driven nucleoside diphosphate kinase synthesis of GTP from GDP is 75fold greater than the polyphosphate synthesis from GTP. GTP and ATP are equally active in polyphosphate synthesis Pseudomonas aeruginosa ?
-
-
2.7.4.34 additional information the polyphosphate-driven nucleoside diphosphate kinase synthesis of GTP from GDP is 75fold greater than the polyphosphate synthesis from GTP. GTP and ATP are equally active in polyphosphate synthesis Pseudomonas aeruginosa DSM 22644 ?
-
-

Subunits

EC Number Subunits Comment Organism
2.7.4.1 ? x * 40800, calculated from sequence Pseudomonas aeruginosa
2.7.4.34 ? x * 40800, calculated from sequence Pseudomonas aeruginosa

Synonyms

EC Number Synonyms Comment Organism
2.7.4.1 PA0141
-
 Pseudomonas aeruginosa
2.7.4.1 PPK2
-
 Pseudomonas aeruginosa
2.7.4.34 PA0141
-
 Pseudomonas aeruginosa
2.7.4.34 PPK2
-
 Pseudomonas aeruginosa