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Literature summary extracted from
- A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia (2019), Proc. Natl. Acad. Sci. USA, 116, 3171-3176 .
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.38 | 8.1 | - |
2-hydroxyethane-1-sulfonate | pH not specified in the publication, temperature not specified in the publication | Bilophila wadsworthia |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.433 | 2-sulfoacetaldehyde + NADH + H+ | Bilophila wadsworthia | - |
isethionate + NAD+ | - |
? | |
| 1.1.1.433 | 2-sulfoacetaldehyde + NADH + H+ | Bilophila wadsworthia 3_1_6 | - |
isethionate + NAD+ | - |
? | |
| 1.1.1.433 | additional information | Bilophila wadsworthia | no substrate: acetaldehyde | ? | - |
- |
|
| 1.1.1.433 | additional information | Bilophila wadsworthia 3_1_6 | no substrate: acetaldehyde | ? | - |
- |
|
| 4.4.1.38 | 2-hydroxyethane-1-sulfonate | Bilophila wadsworthia | - |
acetaldehyde + H+ + sulfite | - |
? | |
| 4.4.1.38 | 2-hydroxyethane-1-sulfonate | Desulfovibrio desulfuricans | - |
acetaldehyde + H+ + sulfite | - |
? | |
| 4.4.1.38 | 2-hydroxyethane-1-sulfonate | Bilophila wadsworthia 3_1_6 | - |
acetaldehyde + H+ + sulfite | - |
? | |
| 4.4.1.38 | additional information | Bilophila wadsworthia | no substrates: alternate organosulfonates, (S)-1,2-propanediol or choline | ? | - |
- |
|
| 4.4.1.38 | additional information | Bilophila wadsworthia 3_1_6 | no substrates: alternate organosulfonates, (S)-1,2-propanediol or choline | ? | - |
- |
|
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.433 | Bilophila wadsworthia | E5Y946 | - |
- |
| 1.1.1.433 | Bilophila wadsworthia 3_1_6 | E5Y946 | - |
- |
| 4.4.1.38 | Bilophila wadsworthia | E5Y378 | - |
- |
| 4.4.1.38 | Bilophila wadsworthia 3_1_6 | E5Y378 | - |
- |
| 4.4.1.38 | Desulfovibrio desulfuricans | B8J0R1 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.433 | 2-sulfoacetaldehyde + NADH + H+ | - |
Bilophila wadsworthia | isethionate + NAD+ | - |
? | |
| 1.1.1.433 | 2-sulfoacetaldehyde + NADH + H+ | - |
Bilophila wadsworthia 3_1_6 | isethionate + NAD+ | - |
? | |
| 1.1.1.433 | additional information | no substrate: acetaldehyde | Bilophila wadsworthia | ? | - |
- |
|
| 1.1.1.433 | additional information | no substrate: acetaldehyde | Bilophila wadsworthia 3_1_6 | ? | - |
- |
|
| 4.4.1.38 | 2-hydroxyethane-1-sulfonate | - |
Bilophila wadsworthia | acetaldehyde + H+ + sulfite | - |
? | |
| 4.4.1.38 | 2-hydroxyethane-1-sulfonate | - |
Desulfovibrio desulfuricans | acetaldehyde + H+ + sulfite | - |
? | |
| 4.4.1.38 | 2-hydroxyethane-1-sulfonate | - |
Bilophila wadsworthia 3_1_6 | acetaldehyde + H+ + sulfite | - |
? | |
| 4.4.1.38 | additional information | no substrates: alternate organosulfonates, (S)-1,2-propanediol or choline | Bilophila wadsworthia | ? | - |
- |
|
| 4.4.1.38 | additional information | no substrates: alternate organosulfonates, (S)-1,2-propanediol or choline | Bilophila wadsworthia 3_1_6 | ? | - |
- |
|
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.433 | HMPREF0179_02714 | - |
Bilophila wadsworthia |
| 1.1.1.433 | sarD | - |
Bilophila wadsworthia |
| 1.1.1.433 | tauF | - |
Bilophila wadsworthia |
| 4.4.1.38 | IslA | - |
Bilophila wadsworthia |
| 4.4.1.38 | IslA | - |
Desulfovibrio desulfuricans |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.38 | 14 | - |
2-hydroxyethane-1-sulfonate | pH not specified in the publication, temperature not specified in the publication | Bilophila wadsworthia | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.1.433 | physiological function | in the taurine desulfonation pathway, an initial deamination of taurine to sulfoacetaldehyde by a taurine:pyruvate aminotransferase is followed by reduction of sulfoacetaldehyde to isethionate (2-hydroxyethanesulfonate) by NADH-dependent reductase SarD. Isethionate is then cleaved to sulfite and acetaldehyde by glycyl radical enzyme isethionate sulfite-lyase IslA | Bilophila wadsworthia |
| 4.4.1.38 | physiological function | taurine desulfonation in Bilophila wadsworthia. An initial deamination of taurine to sulfoacetaldehyde by taurine:pyruvate aminotransferase is followed, by reduction of sulfoacetaldehyde to isethionate (2-hydroxyethanesulfonate) by an NADH-dependent reductase. Isethionate is then cleaved to sulfite and acetaldehyde by glycyl radical enzyme, isethionate sulfite-lyase IslA | Bilophila wadsworthia |
kcat/KM [mM/s]
| EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.38 | 1.2 | - |
2-hydroxyethane-1-sulfonate | pH not specified in the publication, temperature not specified in the publication | Desulfovibrio desulfuricans | |
| 4.4.1.38 | 1.8 | - |
2-hydroxyethane-1-sulfonate | pH not specified in the publication, temperature not specified in the publication | Bilophila wadsworthia | |
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