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Literature summary extracted from

  • Parsons, J.B.; Broussard, T.C.; Bose, J.L.; Rosch, J.W.; Jackson, P.; Subramanian, C.; Rock, C.O.
    Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus (2014), Proc. Natl. Acad. Sci. USA, 111, 10532-10537 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.2.18 expressed in Escherichia coli BL21(DE3) cells Staphylococcus aureus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.2.18 240000
-
 FakA, gel filtration Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.18 Staphylococcus aureus
-
-
-
2.7.2.18 Staphylococcus aureus USA300
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.18 ATP + myristic acid
-
 Staphylococcus aureus ADP + myristyl phosphate
-
 ?
2.7.2.18 ATP + myristic acid
-
 Staphylococcus aureus USA300 ADP + myristyl phosphate
-
 ?
2.7.2.18 ATP + oleic acid
-
 Staphylococcus aureus ADP + oleyl phosphate
-
 ?
2.7.2.18 ATP + oleic acid
-
 Staphylococcus aureus USA300 ADP + oleyl phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.2.18 homodimer FakA, analytical ultracentrifugation Staphylococcus aureus

Synonyms

EC Number Synonyms Comment Organism
2.7.2.18 FA kinase
-
 Staphylococcus aureus
2.7.2.18 FAK
-
 Staphylococcus aureus
2.7.2.18 fakA FakA provides the ATP binding domain and interacts with two distinct FakB protein to produce acyl phosphate Staphylococcus aureus
2.7.2.18 fakB FakB is a fatty acid binding protein. FakB1 selectively binds saturated fatty acids whereas FakB2 prefers unsaturated fatty acids Staphylococcus aureus