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Literature summary extracted from

  • Armingol, E.; Tobar, E.; Cabrera, R.
    Understanding the impact of the cofactor swapping of isocitrate dehydrogenase over the growth phenotype of Escherichia coli on acetate by using constraint-based modeling (2018), PLoS ONE, 13, e0196182 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.41 expressed in Escherichia coli Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.41 Mg2+ 5 mM used in assay conditions Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.41 isocitrate + NAD+ Escherichia coli
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Escherichia coli
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.41 culture condition:acetate-grown cell
-
 Escherichia coli
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 isocitrate + NAD+
-
 Escherichia coli 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.41 NAD+-dependent ICDH
-
 Escherichia coli
1.1.1.41 NAD+-specific ICDH
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
1.1.1.41 physiological function the cofactor swapping of the enzyme from NADPH to NADH decreases the biomass yield of Escherichia coli on acetate Escherichia coli