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Literature summary extracted from

  • Murakami, E.; Shionoya, T.; Komenoi, S.; Suzuki, Y.; Sakane, F.
    Cloning and characterization of novel testis-specific diacylglycerol kinase eta splice variants 3 and 4 (2016), PLoS ONE, 11, e0162997 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.107 expressed in COS-7 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 cytoplasm when osmotically shocked with 0.5 M sorbitol, isoform DGKeta4 is distributed in punctate vesicles in the cytoplasm Homo sapiens 5737
-
2.7.1.107 plasma membrane when osmotically shocked with 0.5 M sorbitol, isoform DGKeta3 is partly translocated to the plasma membrane and co-localizes with the actin cytoskeleton Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Homo sapiens
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Homo sapiens Q86XP1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 NEC-8 cell
-
 Homo sapiens
-
2.7.1.107 spermatid expressed in round spermatids Homo sapiens
-
2.7.1.107 spermatocyte expressed in the secondary spermatocytes Homo sapiens
-
2.7.1.107 testis isoform DGKeta is testis-specific Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-dioleoyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 additional information enzymatically active splice variant DGKeta3 lacks exon 26 encoding 31 amino acid residues. Splice variant DGKeta4 lacks the C-terminal half of variant DGKeta3 and has no enzymatic activity Homo sapiens ?
-
-

Subunits

EC Number Subunits Comment Organism
2.7.1.107 ? x * 124000, isoform DGKeta3, calculated from amino acid sequence Homo sapiens
2.7.1.107 ? x * 126000, isoform DGKeta3, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKeta3 splice variant Homo sapiens
2.7.1.107 DGKeta4 splice variant Homo sapiens
2.7.1.107 diacylglycerol kinase eta isoform Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.107 physiological function isoform DGKeta3 plays specialized roles in spermatogenesis Homo sapiens