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Literature summary extracted from

  • Jeckelmann, J.M.; Erni, B.
    Transporters of glucose and other carbohydrates in bacteria (2020), Pflugers Arch., 472, 1129-1153 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.199 SgrT allosteric inhibitor Escherichia coli
2.7.1.207 additional information dephospho-IIAGlc inhibits the enzyme in the presence of glucose Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-glucose[side 1] Escherichia coli
-
 [protein]-L-histidine + D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.207 [protein]-Npi-phospho-L-histidine + lactose[side 1] Escherichia coli
-
 [protein]-L-histidine + lactose 6'-phosphate[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.199 Escherichia coli P69786
-
-
2.7.1.207 Escherichia coli P02920
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.199 phosphoprotein the enzyme is phosphorylated at C421 of the B-domain Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-glucose[side 1]
-
 Escherichia coli [protein]-L-histidine + D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.207 [protein]-Npi-phospho-L-histidine + lactose[side 1]
-
 Escherichia coli [protein]-L-histidine + lactose 6'-phosphate[side 2]
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.199 homodimer ecIICBGlc is a dimer of subunits consisting of two domains, the N-terminal transport domain IIC and the cytoplasmic phosphorylation domain IIB Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.7.1.199 ecIICBGlc
-
 Escherichia coli
2.7.1.199 PtsG
-
 Escherichia coli
2.7.1.207 lactose permease
-
 Escherichia coli
2.7.1.207 lactose transporter
-
 Escherichia coli
2.7.1.207 lacY
-
 Escherichia coli