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Literature summary extracted from

  • Sudhakara, S.; Chadha, A.
    A carbonyl reductase from Candida parapsilosis ATCC 7330 substrate selectivity and enantiospecificity (2017), Org. Biomol. Chem., 15, 4165-4171 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 Cu2+ the enzyme activity is affected by Cu2+ Candida parapsilosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.184 4-nitrobenzaldehyde + NADPH + H+ Candida parapsilosis
-
 4-nitrobenzylalcohol + NADP+
-
 ?
1.1.1.184 4-nitrobenzaldehyde + NADPH + H+ Candida parapsilosis ATCC 7330
-
 4-nitrobenzylalcohol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Candida parapsilosis M4VRJ6
-
-
1.1.1.184 Candida parapsilosis ATCC 7330 M4VRJ6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 2-chloroacetophenone + NADPH + H+ 100% conversion Candida parapsilosis (RS)-2-chloro-1-phenylethan-1-ol + NADP+
-
 ?
1.1.1.184 2-chloroacetophenone + NADPH + H+ 100% conversion Candida parapsilosis ATCC 7330 (RS)-2-chloro-1-phenylethan-1-ol + NADP+
-
 ?
1.1.1.184 2-hydroxyacetophenone + NADPH + H+ 100% conversion, more than 99% S-enantiomeric excess Candida parapsilosis (RS)-1-phenyl-1,2-ethanediol + NADP+
-
 ?
1.1.1.184 2-hydroxyacetophenone + NADPH + H+ 100% conversion, more than 99% S-enantiomeric excess Candida parapsilosis ATCC 7330 (RS)-1-phenyl-1,2-ethanediol + NADP+
-
 ?
1.1.1.184 4-nitrobenzaldehyde + NADPH + H+
-
 Candida parapsilosis 4-nitrobenzylalcohol + NADP+
-
 ?
1.1.1.184 4-nitrobenzaldehyde + NADPH + H+
-
 Candida parapsilosis ATCC 7330 4-nitrobenzylalcohol + NADP+
-
 ?
1.1.1.184 ethyl-2-oxo-2-phenylacetate + NADH + H+ 86% conversion Candida parapsilosis (RS)-ethyl-2-hydroxy-2-phenylacetate + NAD+
-
 ?
1.1.1.184 ethyl-2-oxo-2-phenylacetate + NADH + H+ 86% conversion Candida parapsilosis ATCC 7330 (RS)-ethyl-2-hydroxy-2-phenylacetate + NAD+
-
 ?
1.1.1.184 ethyl-2-oxo-2-phenylacetate + NADPH + H+ 100% conversion, 70% S-enantiomeric excess Candida parapsilosis (RS)-ethyl-2-hydroxy-2-phenylacetate + NADP+
-
 ?
1.1.1.184 ethyl-2-oxo-4-phenylbutanoate + NADH + H+ 84% conversion Candida parapsilosis (RS)-ethyl-2-hydroxy-4-phenylbutanoate + NAD+
-
 ?
1.1.1.184 ethyl-2-oxo-4-phenylbutanoate + NADPH + H+ 98% conversion, 70% S-enantiomeric excess Candida parapsilosis (RS)-ethyl-2-hydroxy-4-phenylbutanoate + NADP+
-
 ?
1.1.1.184 additional information no reaction with 2-chloroacetophenone plus NADH or 2-hydroxyacetophenone plus NADH Candida parapsilosis ?
-
-
1.1.1.184 additional information no reaction with 2-chloroacetophenone plus NADH or 2-hydroxyacetophenone plus NADH Candida parapsilosis ATCC 7330 ?
-
-

Subunits

EC Number Subunits Comment Organism
1.1.1.184 ? x * 27000, SDS-PAGE Candida parapsilosis

Synonyms

EC Number Synonyms Comment Organism
1.1.1.184 (S)-specific carbonyl reductase
-
 Candida parapsilosis
1.1.1.184 SRED
-
 Candida parapsilosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.184 25
-
-
 Candida parapsilosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.184 5
-
-
 Candida parapsilosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.184 NADH
-
 Candida parapsilosis
1.1.1.184 NADPH
-
 Candida parapsilosis