EC Number | Cloned (Comment) | Organism |
---|---|---|
2.8.3.5 | gene OXCT1 , transient overexpression of OXCT1 in SK-OV-3 OC cells, the level of OXCT1 expresxadsion is increased to 161.5fold in OXCT1-transfected cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.8.3.5 | additional information | sensitization of cells to cisplatin following overexpression of OXCT1 , overexpression of OXCT1 enhances sensitivity to cisplatin, one of the most effective broad-spectrum anticancer drugs, in the SK-OV-3 OC ovarian cancer cell line. Overexpression of OXCT1 significantly decreases the IC50 for cisplatin by about 21% compared with EGFP-transfected control cells | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.8.3.5 | mitochondrial matrix | - |
Homo sapiens | 5759 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.8.3.5 | Homo sapiens | P55809 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.8.3.5 | A-2780 cell | - |
Homo sapiens | - |
2.8.3.5 | CAOV-3 cell | - |
Homo sapiens | - |
2.8.3.5 | OV-90 cell | - |
Homo sapiens | - |
2.8.3.5 | ovary cancer cell | - |
Homo sapiens | - |
2.8.3.5 | OVCAR-3 cell | - |
Homo sapiens | - |
2.8.3.5 | PA-1 cell | - |
Homo sapiens | - |
2.8.3.5 | SKOV-3 cell | - |
Homo sapiens | - |
2.8.3.5 | TOV-112D cell | - |
Homo sapiens | - |
2.8.3.5 | TOV-21G cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.8.3.5 | succinyl-CoA + a 3-oxo acid | - |
Homo sapiens | succinate + a 3-oxoacyl-CoA | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.8.3.5 | homodimer | - |
Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.8.3.5 | 3-oxoacid CoA transferase 1 | - |
Homo sapiens |
2.8.3.5 | OXCT1 | - |
Homo sapiens |
2.8.3.5 | OXCT1 encodes 3-oxoacid-coenzyme A transferase 1 | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.8.3.5 | Homo sapiens | OXCT1 expression is suppressed by DNA methylation in the cisplatin-resistant group | down |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.8.3.5 | malfunction | overexpression of OXCT1 enhances sensitivity to cisplatin in the SK-OV-3 OC cell line | Homo sapiens |
2.8.3.5 | physiological function | 3-oxoacid-CoA transferase 1 (OXCT1) is a homodimeric mitochondrial matrix enzyme that serves a central role in extrahepatic ketone body catabolism (ketone bodies to acetyl-CoA to mitochondrial tricarboxylic acid cycle entrance). OXCT1 overexpression in a cisplatin-resistant cell line improves sensitivity to cisplatin. Natural sensitivity to cisplatin is observed in the eight human ovarian cell lines SK-OV-3, PA-1, Caov-3, TOV-21 G, TOV-112D, OV-90, OVCAR-3 and A2780 | Homo sapiens |