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Literature summary extracted from

  • Yang, S.D.; Ahn, S.H.; Kim, J.I.
    3-Oxoacid CoA transferase 1 as a therapeutic target gene for cisplatin-resistant ovarian cancer (2018), Oncol. Lett., 15, 2611-2618 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.3.5 gene OXCT1 , transient overexpression of OXCT1 in SK-OV-3 OC cells, the level of OXCT1 expresxadsion is increased to 161.5fold in OXCT1-transfected cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.8.3.5 additional information sensitization of cells to cisplatin following overexpression of OXCT1 , overexpression of OXCT1 enhances sensitivity to cisplatin, one of the most effective broad-spectrum anticancer drugs, in the SK-OV-3 OC ovarian cancer cell line. Overexpression of OXCT1 significantly decreases the IC50 for cisplatin by about 21% compared with EGFP-transfected control cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.3.5 mitochondrial matrix
-
Homo sapiens 5759
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.5 Homo sapiens P55809
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.3.5 A-2780 cell
-
Homo sapiens
-
2.8.3.5 CAOV-3 cell
-
Homo sapiens
-
2.8.3.5 OV-90 cell
-
Homo sapiens
-
2.8.3.5 ovary cancer cell
-
Homo sapiens
-
2.8.3.5 OVCAR-3 cell
-
Homo sapiens
-
2.8.3.5 PA-1 cell
-
Homo sapiens
-
2.8.3.5 SKOV-3 cell
-
Homo sapiens
-
2.8.3.5 TOV-112D cell
-
Homo sapiens
-
2.8.3.5 TOV-21G cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.5 succinyl-CoA + a 3-oxo acid
-
Homo sapiens succinate + a 3-oxoacyl-CoA
-
?

Subunits

EC Number Subunits Comment Organism
2.8.3.5 homodimer
-
Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.8.3.5 3-oxoacid CoA transferase 1
-
Homo sapiens
2.8.3.5 OXCT1
-
Homo sapiens
2.8.3.5 OXCT1 encodes 3-oxoacid-coenzyme A transferase 1
-
Homo sapiens

Expression

EC Number Organism Comment Expression
2.8.3.5 Homo sapiens OXCT1 expression is suppressed by DNA methylation in the cisplatin-resistant group down

General Information

EC Number General Information Comment Organism
2.8.3.5 malfunction overexpression of OXCT1 enhances sensitivity to cisplatin in the SK-OV-3 OC cell line Homo sapiens
2.8.3.5 physiological function 3-oxoacid-CoA transferase 1 (OXCT1) is a homodimeric mitochondrial matrix enzyme that serves a central role in extrahepatic ketone body catabolism (ketone bodies to acetyl-CoA to mitochondrial tricarboxylic acid cycle entrance). OXCT1 overexpression in a cisplatin-resistant cell line improves sensitivity to cisplatin. Natural sensitivity to cisplatin is observed in the eight human ovarian cell lines SK-OV-3, PA-1, Caov-3, TOV-21 G, TOV-112D, OV-90, OVCAR-3 and A2780 Homo sapiens