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Literature summary extracted from

  • Munoz-Vargas, M.A.; Gonzalez-Gordo, S.; Canas, A.; Lopez-Jaramillo, J.; Palma, J.M.; Corpas, F.J.
    Endogenous hydrogen sulfide (H2S) is up-regulated during sweet pepper (Capsicum annuum L.) fruit ripening. In vitro analysis shows that NADP-dependent isocitrate dehydrogenase (ICDH) activity is inhibited by H2S and NO (2018), Nitric Oxide, 81, 36-45 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 DEA-NONOate 48% reduction of activity at 5 mM Capsicum annuum
1.1.1.42 hydrogen sulfide
-
 Capsicum annuum
1.1.1.42 additional information not affected by glutathione Capsicum annuum
1.1.1.42 Na2S around 23% inhibition with 1 to 5 mM Na2S Capsicum annuum
1.1.1.42 NaHS 2 and 10 mM NaHS used as H2S donors result in a decrease in enzyme activity of up to 36% and 45%, respectively Capsicum annuum
1.1.1.42 nitric oxide
-
 Capsicum annuum
1.1.1.42 peroxynitrite causes a 26% inhibition in enzyme activity with 5 mM SIN-1 Capsicum annuum
1.1.1.42 S-nitrosocysteine 96% reduction of activity at 5 mM Capsicum annuum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Capsicum annuum
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Capsicum annuum A0A2G2Y555 cultvar Melchor
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.42 nitration the enzyme protein is a target of inhibitory nitric oxide-mediated posttranslational modification (nitration) Capsicum annuum
1.1.1.42 S-nitrosylation the enzyme protein is a target of inhibitory H2S-mediated posttranslational modification (S-nitrosylation) Capsicum annuum

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.42 ammonium sulfate precipitation Capsicum annuum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 fruit
-
 Capsicum annuum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
 Capsicum annuum 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 ICDH
-
 Capsicum annuum
1.1.1.42 NADP-dependent isocitrate dehydrogenase
-
 Capsicum annuum
1.1.1.42 NADP-ICDH
-
 Capsicum annuum
1.1.1.42 NADP-isocitrate dehydrogenase
-
 Capsicum annuum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
 Capsicum annuum

Expression

EC Number Organism Comment Expression
1.1.1.42 Capsicum annuum enzyme expression increases 1.7fold during pepper fruit ripening up