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Literature summary extracted from

  • Blechner, C.; Becker, L.; Fuchs, H.; Rathkolb, B.; Prehn, C.; Adler, T.; Calzada-Wack, J.; Garrett, L.; Gailus-Durner, V.; Morellini, F.; Conrad, S.; Hoelter, S.M.; Wolf, E.; Klopstock, T.; Adamski, J.; Busch, D.; de Angelis, M.H.; Schmeisser, M.J.; Windhorst, S.
    Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice (2020), Neurosci. Lett., 735, 135206 .
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
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ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Mus musculus Q8R071
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 brain ITPKA is mainly expressed in pyramidal cells of the hippocampal CA1 region and granule cells of the dentate gyrus Mus musculus
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2.7.1.127 Caco-2 cell
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Mus musculus
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2.7.1.127 carcinoma cell
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Mus musculus
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2.7.1.127 central nervous system
-
Mus musculus
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2.7.1.127 dentate gyrus
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Mus musculus
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2.7.1.127 granule cell
-
Mus musculus
-
2.7.1.127 hippocampus
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Mus musculus
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2.7.1.127 lung cancer cell
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Mus musculus
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2.7.1.127 additional information isozyme ITPKA is mainly expressed in neurons of the central nervous system and is also overexpressed in tumor cells Mus musculus
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2.7.1.127 neuron in mature neurons, ITPKA accumulates at postsynaptic densities (PSDs), where the protein is bound to F-actin Mus musculus
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2.7.1.127 pyramidal neuron
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Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
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Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 inositol-1,4,5-trisphosphate 3-kinase
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Mus musculus
2.7.1.127 InsP3Kinase
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Mus musculus
2.7.1.127 ITPKA
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Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.127 malfunction Itpka-deficient mice exhibit a weak metabolic phenotype, in keeping with functional studies revealing no clear role of ITPKA in metabolic organs. Broad phenotypic screening of itpka-deficient mice, Effects of itpka deficiency on brain function, overview. Among the neurobehavioral tests analyzed, itpka-deficient mice reacted faster to a hot plate, prepulse inhibition is impaired and the accelerating rotarod test shows decreased latency of itpka deficient mice to fall. Analysis of extracerebral functions in control and itpka deficient mice reveals significantly reduced glucose, lactate, and triglyceride plasma concentrations in itpka-deficient mice. Itpka deficiency affects energy metabolism, phenotype. Reduced glucose level is measured in plasma of itpka-deficient mice Mus musculus
2.7.1.127 physiological function isozyme ITPKA is involved in the regulation of nociceptive pathways, sensorimotor gating, and motor learning. Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is the neuronal isoform of ITPKs and exhibits both actin bundling and InsP3 kinase activity. In addition to neurons, ITPKA is ectopically expressed in tumor cells, where its oncogenic activity increases tumor cell malignancy. ITPKA is involved in the regulation of nociceptive pathways, sensorimotor gating and motor learning. ITPKA plays a functional role in calcium signaling of CaCo-2 cells Mus musculus