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Literature summary extracted from

  • Shearer, F.J.G.; Wyrwoll, C.S.; Holmes, M.C.
    The role of 11beta-hydroxy steroid dehydrogenase type 2 in glucocorticoid programming of affective and cognitive behaviours (2019), Neuroendocrinology, 109, 257-265 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisol + NAD+ Mus musculus
-
 cortisone + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Mus musculus P51661
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 brain
-
 Mus musculus
-
1.1.1.146 fetus
-
 Mus musculus
-
1.1.1.146 placenta
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NAD+
-
 Mus musculus cortisone + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxy steroid dehydrogenase type 2
-
 Mus musculus
1.1.1.146 HSD2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.1.1.146 malfunction feto-placental deletion of isoform HSD2 results in a reduced birthweight and the development of anxiety- and depression-like behaviours in adult mice. Brain-specific HSD2 removal also generates adult phenotypes of depressive-like behaviour and memory deficits Mus musculus
1.1.1.146 physiological function isoform HSD2 expression protects the serotonin system in development Mus musculus