Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ogasawara, Y.; Cheng, J.; Tatematsu, T.; Uchida, M.; Murase, O.; Yoshikawa, S.; Ohsaki, Y.; Fujimoto, T.
    Long-term autophagy is sustained by activation of CCTbeta3 on lipid droplets (2020), Nat. Commun., 11, 4480 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + phosphocholine Mus musculus
-
 diphosphate + CDP-choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 embryo
-
 Mus musculus
-
2.7.7.15 fibroblast embryonic Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + phosphocholine
-
 Mus musculus diphosphate + CDP-choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 CCTbeta3
-
 Mus musculus
2.7.7.15 CTP:phosphocholine cytidylyltransferase beta3
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.7.15 drug target CTP:phosphocholine cytidylyltransferase beta3 (CCTbeta3) may be targeted to suppress prolonged autophagy in cancer cells in vivo Mus musculus
2.7.7.15 physiological function phosphatidylcholine synthesis through CCTbeta3 (CTP:phosphocholine cytidylyltransferase beta3) activation on lipid droplets is crucial for sustaining autophagy and long-term cell survival Mus musculus