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Literature summary extracted from

  • Imbert, C.; Montfort, A.; Fraisse, M.; Marcheteau, E.; Gilhodes, J.; Martin, E.; Bertrand, F.; Marcellin, M.; Burlet-Schiltz, O.; Peredo, A.G.; Garcia, V.; Carpentier, S.; Tartare-Deckert, S.; Brousset, P.; Rochaix, P.; Puisset, F.; Filleron, T.; Meyer, N.; Lamant, L.; Levade, T.; Segui, B.; Andrieu-Abadie, N.; Colacios, C.
    Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1 (2020), Nat. Commun., 11, 437 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.91 medicine sphingosine kinase-1 expression inversely correlates with survival after immune checkpoint inhibitor (ICI) therapy in melanoma tumors. Downregulation of sphingosine kinase-1 improves the efficacy of ICI therapy in various cancer models Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.91 ATP + sphingosine Homo sapiens
-
 ADP + sphingosine 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Homo sapiens Q9NYA1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 melanoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 SK1 isoform Homo sapiens
2.7.1.91 sphingosine kinase-1
-
 Homo sapiens
2.7.1.91 SPHK1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.91 Homo sapiens sphingosine kinase-1 transcript levels are higher in human primary melanomas as compared to nevi up

General Information

EC Number General Information Comment Organism
2.7.1.91 malfunction sphingosine kinase-1 silencing decreases the expression of various immunosuppressive factors in the tumor microenvironment to limit regulatory T cell infiltration Homo sapiens
2.7.1.91 physiological function sphingosine kinase-1 is a key regulator of anti-tumor immunity. Increased expression of the enzyme in tumor cells is significantly associated with shorter survival in metastatic melanoma patients treated with anti-programmed cell death protein-1 Homo sapiens