Literature summary extracted from

Hua, Z.S.; Wang, Y.L.; Evans, P.N.; Qu, Y.N.; Goh, K.M.; Rao, Y.Z.; Qi, Y.L.; Li, Y.X.; Huang, M.J.; Jiao, J.Y.; Chen, Y.T.; Mao, Y.P.; Shu, W.S.; Hozzein, W.; Hedlund, B.P.; Tyson, G.W.; Zhang, T.; Li, W.J.
Insights into the ecological roles and evolution of methyl-coenzyme M reductase-containing hot spring Archaea (2019), Nat. Commun., 10, 4574 .

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.8.4.1	gene mcr, sequencing and analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis	Thaumarchaeota
2.8.4.1	gene mcr, sequencing and analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis	Candidatus Verstraetearchaeota
2.8.4.1	gene mcr, sequencing and analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis	Candidatus Nezhaarchaeota archaeon
2.8.4.1	gene mcr, sequencing and analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis	Hadesarchaea archaeon
2.8.4.1	gene mcr, sequencing and analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis	Archaeoglobi

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.8.4.1	methyl-CoM + CoB	Thaumarchaeota	-	CoM-S-S-CoB + methane	-	?
2.8.4.1	methyl-CoM + CoB	Candidatus Verstraetearchaeota	-	CoM-S-S-CoB + methane	-	?
2.8.4.1	methyl-CoM + CoB	Candidatus Nezhaarchaeota archaeon	-	CoM-S-S-CoB + methane	-	?
2.8.4.1	methyl-CoM + CoB	Hadesarchaea archaeon	-	CoM-S-S-CoB + methane	-	?
2.8.4.1	methyl-CoM + CoB	Archaeoglobi	-	CoM-S-S-CoB + methane	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.8.4.1	Archaeoglobi	-	-	-
2.8.4.1	Candidatus Nezhaarchaeota archaeon	-	-	-
2.8.4.1	Candidatus Verstraetearchaeota	-	-	-
2.8.4.1	Hadesarchaea archaeon	-	-	-
2.8.4.1	Thaumarchaeota	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.8.4.1	methyl-CoM + CoB	-	Thaumarchaeota	CoM-S-S-CoB + methane	-	?
2.8.4.1	methyl-CoM + CoB	-	Candidatus Verstraetearchaeota	CoM-S-S-CoB + methane	-	?
2.8.4.1	methyl-CoM + CoB	-	Candidatus Nezhaarchaeota archaeon	CoM-S-S-CoB + methane	-	?
2.8.4.1	methyl-CoM + CoB	-	Hadesarchaea archaeon	CoM-S-S-CoB + methane	-	?
2.8.4.1	methyl-CoM + CoB	-	Archaeoglobi	CoM-S-S-CoB + methane	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.8.4.1	MCR	-	Thaumarchaeota
2.8.4.1	MCR	-	Candidatus Verstraetearchaeota
2.8.4.1	MCR	-	Candidatus Nezhaarchaeota archaeon
2.8.4.1	MCR	-	Hadesarchaea archaeon
2.8.4.1	MCR	-	Archaeoglobi
2.8.4.1	methyl-coenzyme M reductase	-	Thaumarchaeota
2.8.4.1	methyl-coenzyme M reductase	-	Candidatus Verstraetearchaeota
2.8.4.1	methyl-coenzyme M reductase	-	Candidatus Nezhaarchaeota archaeon
2.8.4.1	methyl-coenzyme M reductase	-	Hadesarchaea archaeon
2.8.4.1	methyl-coenzyme M reductase	-	Archaeoglobi

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.8.4.1	F-430	coenzyme F430	Thaumarchaeota
2.8.4.1	F-430	coenzyme F430	Candidatus Verstraetearchaeota
2.8.4.1	F-430	coenzyme F430	Candidatus Nezhaarchaeota archaeon
2.8.4.1	F-430	coenzyme F430	Hadesarchaea archaeon
2.8.4.1	F-430	coenzyme F430	Archaeoglobi

General Information

EC Number	General Information	Comment	Organism
2.8.4.1	evolution	analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis, and evolution of methyl-coenzyme M reductase-containing hot spring Archaea, overview. A hydrothermal origin for these microorganisms is predicted based on optimal growth temperature predictions. Methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor	Thaumarchaeota
2.8.4.1	evolution	analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis, and evolution of methyl-coenzyme M reductase-containing hot spring Archaea, overview. A hydrothermal origin for these microorganisms is predicted based on optimal growth temperature predictions. Methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor	Candidatus Nezhaarchaeota archaeon
2.8.4.1	evolution	analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis, and evolution of methyl-coenzyme M reductase-containing hot spring Archaea, overview. A hydrothermal origin for these microorganisms is predicted based on optimal growth temperature predictions. Methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor	Hadesarchaea archaeon
2.8.4.1	evolution	analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis, and evolution of methyl-coenzyme M reductase-containing hot spring Archaea, overview. A hydrothermal origin for these microorganisms is predicted based on optimal growth temperature predictions. Methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor	Archaeoglobi
2.8.4.1	evolution	analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis, and evolution of methyl-coenzyme M reductase-containing hot spring Archaea, overview. A hydrothermal origin for these microorganisms is predicted based on optimal growth temperature predictions. Methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor. Five mcr-containing MAGs are identified as Verstraetearchaeota	Candidatus Verstraetearchaeota
2.8.4.1	metabolism	overview of metabolic potentials in mcr-containing MAGs	Thaumarchaeota
2.8.4.1	metabolism	overview of metabolic potentials in mcr-containing MAGs	Candidatus Verstraetearchaeota
2.8.4.1	metabolism	overview of metabolic potentials in mcr-containing MAGs	Candidatus Nezhaarchaeota archaeon
2.8.4.1	metabolism	overview of metabolic potentials in mcr-containing MAGs	Hadesarchaea archaeon
2.8.4.1	metabolism	overview of metabolic potentials in mcr-containing MAGs	Archaeoglobi

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Release 2023.1 (January 2023)