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Literature summary extracted from

  • Xing, M.; Wei, Y.; Zhou, Y.; Zhang, J.; Lin, L.; Hu, Y.; Hua, G.; N. Nanjaraj Urs, A.; Liu, D.; Wang, F.; Guo, C.; Tong, Y.; Li, M.; Liu, Y.; Ang, E.; Zhao, H.; Yuchi, Z.; Zhang, Y.
    Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria (2019), Nat. Commun., 10, 1609 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.4.1.38 in complex with isethionate, to 2.4 A resolution. space group P21, crystals contain four monomers per asymmetric unit, each exhibiting a canonical beta/alpha barrel fold Desulfovibrio vulgaris

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.38 44.8
-
 isethionate pH not specified in the publication, temperature not specified in the publication Desulfovibrio vulgaris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.433 2-sulfoacetaldehyde + NADH + H+ Bilophila wadsworthia
-
 isethionate + NAD+
-
 ?
1.1.1.433 2-sulfoacetaldehyde + NADH + H+ Bilophila wadsworthia 3_1_6
-
 isethionate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.433 Bilophila wadsworthia E5Y946
-
-
1.1.1.433 Bilophila wadsworthia 3_1_6 E5Y946
-
-
4.4.1.38 Desulfovibrio vulgaris Q727N1
-
-
4.4.1.38 Desulfovibrio vulgaris ATCC 29579 Q727N1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.433 2-sulfoacetaldehyde + NADH + H+
-
 Bilophila wadsworthia isethionate + NAD+
-
 ?
1.1.1.433 2-sulfoacetaldehyde + NADH + H+
-
 Bilophila wadsworthia 3_1_6 isethionate + NAD+
-
 ?
4.4.1.38 isethionate
-
 Desulfovibrio vulgaris acetaldehyde + H+ + sulfite
-
 ?
4.4.1.38 isethionate
-
 Desulfovibrio vulgaris ATCC 29579 acetaldehyde + H+ + sulfite
-
 ?
4.4.1.38 additional information no substrates: taurine or ethanolamine Desulfovibrio vulgaris ?
-
-
4.4.1.38 additional information no substrates: taurine or ethanolamine Desulfovibrio vulgaris ATCC 29579 ?
-
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.433 tauF
-
 Bilophila wadsworthia
4.4.1.38 GUF
-
 Desulfovibrio vulgaris
4.4.1.38 IseG
-
 Desulfovibrio vulgaris

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.4.1.38 91.6
-
 isethionate pH not specified in the publication, temperature not specified in the publication Desulfovibrio vulgaris

General Information

EC Number General Information Comment Organism
1.1.1.433 physiological function involved in taurine degradation in human gut. TauF catalyzes NADH-dependent reduction of sulfoacetaldehyde, generating isethionate that is subsequently cleaved by sulfonate C-S lyase IseG Bilophila wadsworthia