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Literature summary extracted from

  • Yue, L.; McPhee, M.J.; Gonzalez, K.; Charman, M.; Lee, J.; Thompson, J.; Winkler, D.F.H.; Cornell, R.B.; Pelech, S.; Ridgway, N.D.
    Differential dephosphorylation of CTP phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets (2020), Mol. Biol. Cell, 31, 1047-1059 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 nuclear membrane nuclear membrane association of CCTa induced by oleate loading is linked to dephosphorylation of S319 Homo sapiens 31965
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + phosphocholine Homo sapiens
-
 diphosphate + CDP-choline
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Homo sapiens P49585
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-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.15 phosphoprotein oleate treatment of cultured cells triggers CCTalpha translocation to the nuclear envelope and nuclear lipid droplets and rapid dephosphorylation of pS319. Removal of oleate leads to dissociation of CCTalpha from the nuclear envelope and increased phosphorylation of S319. Choline depletion of cells causes CCTalpha translocation to the nuclear envelope and S319 dephosphorylation. Y359 and S362 are constitutively phosphorylated during oleate addition and removal. The P-domain undergoes negative charge polarization due to dephosphorylation of S319 and possibly other proline-directed sites and retention of Y359 and S362 phosphorylation. Dephosphorylation of S319 and S315 is involved in CCTalpha recruitment to nuclear membranes Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + phosphocholine
-
 Homo sapiens diphosphate + CDP-choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 CCTalpha
-
 Homo sapiens
2.7.7.15 CTP:phosphocholine cytidylyltransferase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.7.15 physiological function CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha) and CCTbeta catalyze the rate limiting step in phosphatidylcholine biosynthesis Homo sapiens