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Literature summary extracted from

  • Lee, H.N.; Jung, H.; Chung, T.
    Subcellular Localization of PI3P in Arabidopsis (2020), Methods Mol. Biol., 2177, 109-118 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 3-Methyladenine 3-MA, a nonspecific inhibitor of PI 3-kinases Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.137 endosome late Arabidopsis thaliana 5768
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.137 Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol Arabidopsis thaliana
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Arabidopsis thaliana P42339
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 root
-
 Arabidopsis thaliana
-
2.7.1.137 root tip
-
 Arabidopsis thaliana
-
2.7.1.137 seed
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Arabidopsis thaliana ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 phosphatidylinositol 3-kinase
-
 Arabidopsis thaliana
2.7.1.137 PI 3-kinase
-
 Arabidopsis thaliana
2.7.1.137 vacuolar protein sorting 34
-
 Arabidopsis thaliana
2.7.1.137 VPS34
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.137 ATP
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.7.1.137 malfunction Arabidopsis thaliana pollen development is abnormal in knockout mutants for shared components of two VPS34 complexes (VPS34, VPS15, and ATG6/VPS30) Arabidopsis thaliana
2.7.1.137 additional information in yeast and mammals, Vps34 homologues are found in at least two distinct PI 3-kinase complexes. The Vps34 complex I, consisting of Vps34, Vps15, autophagy-related 6 (Atg6)/Vps30, and Atg14, regulates an early step of autophagy at the site of autophagosome formation, whereas the Vps34 complex II containing Vps34, Vps15, Atg6/ Vps30, and Vps38 (or UVRAG in mammals) is involved in vacuolar protein sorting and localized to the endosome Arabidopsis thaliana