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Literature summary extracted from

  • Li, Z.; Chen, Y.; Meesapyodsuk, D.; Qiu, X.
    The biosynthetic pathway of major avenanthramides in oat (2019), Metabolites, 9, 163 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.302 expression in Escherichia coli Avena sativa

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.302 Avena sativa A0A4Y5UJ70 isoform HHT4
-
2.3.1.302 Avena sativa Q7XXP3 isoform HHT1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.302 caffeoyl-CoA + 5-hydroxyanthranilate
-
 Avena sativa avenanthramide C + CoA
-
 ?
2.3.1.302 additional information no substrate: feruloyl-CoA Avena sativa ?
-
-
2.3.1.302 p-coumaroyl-CoA + 5-hydroxyanthranilate
-
 Avena sativa avenanthramide A + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.302 HHT1
-
 Avena sativa
2.3.1.302 HHT4
-
 Avena sativa

General Information

EC Number General Information Comment Organism
2.3.1.302 physiological function oat HHTs are responsible for the biosynthesis of avenanthramide A and avenanthramide C using hydroxyanthranilic acid as an acyl acceptor and p-coumaroyl-CoA and caffeoyl-CoA as an acyl donor, respectively. Contrary, avenanthramide B is synthesized by a caffeoyl-CoA O-methyltransferase enzyme through the methylation of avenanthramide C Avena sativa